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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies. In total, data from 764 participants were compared across five in vivo imaging methods. Convergence of effects was seen in posterior cortical regions, including posterior cingulate, retrosplenial, and lateral parietal cortex. These regions were active in default states in young adults and also showed amyloid deposition in older adults with AD. At early stages of AD progression, prominent atrophy and metabolic abnormalities emerged in these posterior cortical regions; atrophy in medial temporal regions was also observed. Event-related functional magnetic resonance imaging studies further revealed that these cortical regions are active during successful memory retrieval in young adults. One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy. These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.

Why it matters

Data from 764 participants across five brain imaging methods showed overlapping effects in posterior cortical regions, including the posterior cingulate. These regions are active in default states in young adults, showed amyloid deposits in older adults with Alzheimer's, and showed atrophy and metabolic abnormalities early in the disease. The authors suggest that lifetime activity in these regions may predispose them to Alzheimer's-related changes.

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How this study scored 57/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 54 of the 95 points we could judge it on, which is 57 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Neuroscience)
Journal's citation record	4 / 4	Journal of Neuroscience: journal h-index 651 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	— / 5	No evidence rating recorded — left out of this score
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2005 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	7 / 7	Cited 2,144 times (OpenAlex, 2026-10-10)
Citations per year	5 / 5	93.2 citations a year over 23 year(s) since 2005
Impact for its field and year	5 / 6	Cited 33.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	4 / 4	Cited 219 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Mark A. Mintun: h-index 131 (OpenAlex, whole career)
Institution's track record	2 / 3	Howard Hughes Medical Institute: institution h-index 2,008 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 16120771)
Free to read	2 / 2	Free to read
Points	54 / 95	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 95 points we could judge it on is 57 out of 100.
Total	57 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 11 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G. N., Sachs, R., Fotenos, A. F., et al. (2005). Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2177-05.2005

Vancouver

Buckner RL, Snyder AZ, Shannon BJ, LaRossa GN, Sachs R, Fotenos AF, et al. Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory. Journal of Neuroscience. 2005. doi:10.1523/jneurosci.2177-05.2005. PMID: 16120771.

BibTeX

@article{buckner2005-16120771,
  author  = {Buckner, Randy Lee and Snyder, Abraham Z. and Shannon, Benjamin J. and LaRossa, Gina N. and Sachs, Rimmon and Fotenos, Anthony F. and Sheline, Yvette I. and Klunk, William E. and Mathis, Chester A. and Morris, John C. and Mintun, Mark A.},
  title   = {{Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory}},
  journal = {Journal of Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2177-05.2005},
  pmid    = {16120771},
  url     = {https://doi.org/10.1523/jneurosci.2177-05.2005}
}

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