Newest studies

Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study

64/100 ✓ Peer-reviewed Vascular contributions Brain : a journal of neurology

Key finding: Larger venular diameters were, however, associated with a marked progression of cerebral small vessel disease. +1 more finding

• Other Dementias
• Risk Factors

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Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma

43/100 ✓ Peer-reviewed Drug development Cancer letters

Key finding: We have previously demonstrated an increase of APP expression in oral squamous cell carcinoma (OSCC) and related OSCC cell lines. +3 more findings

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Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease

43/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of neurology, neurosurgery, and psychiatry

Key finding: Hippocampal atrophy is not only a characteristic of Alzheimer's disease but also occurs in FTLD. +4 more findings

• Brain Scans
• Other Dementias

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Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease

45/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neurochemistry

Key finding: Advancements in molecular, cellular, and animal model studies have revealed that the formation of amyloid beta (Abeta) and other derivatives of the amyloid precursor protein (APP) are key factors in cellular changes in the AD brain, including the generation of free radicals, oxidative damage, and inflammation. +3 more findings

• Brain Biology

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Epidemiology and risk factors of dementia

71/100 ✓ Peer-reviewed Risk factors Journal of Neurology Neurosurgery & Psychiatry

Key finding: PREVALENCEPrevalence is defined as the proportion of a population that has disease at a specific point in time.

• Risk Factors

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

48/100 ✓ Peer-reviewed Risk genes beyond APOE PLoS medicine

Key finding: The proteases (secretases) that cleave amyloid-beta (Abeta) peptide from the amyloid precursor protein (APP) have been the focus of considerable investigation in the development of treatments for Alzheimer disease. +3 more findings

• Brain Biology

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Visual dysfunction in Parkinson disease without dementia

40/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: Patients with mild to moderate Parkinson disease showed impaired visual perception and cognition compared with elderly control subjects. +1 more finding

• Other Dementias

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Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

41/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: Individuals with eAD had significantly fewer synapses than the other two diagnostic groups. +4 more findings

• Brain Biology
• Early Stage
• Genetics

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Do‐Not‐Resuscitate and Do‐Not‐Hospitalize Directives of Persons Admitted to Skilled Nursing Facilities Under the Medicare Benefit

57/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: Thirty-two percent of residents had DNR directives, whereas less than 2% had DNH directives. +4 more findings

• Policy
• Health Equity

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Cognitive decline and dementia in diabetes--systematic overview of prospective observational studies

61/100 ✓ Peer-reviewed Getting a diagnosis Diabetologia

Key finding: Compared to people without diabetes, people with diabetes have a greater rate of decline in cognitive function and a greater risk of cognitive decline. +1 more finding

• Diagnosis
• Risk Factors

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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

51/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: Potent, reversible, and brain-targeted BChE inhibitors (cymserine analogs) were developed based on binding domain structures to help elucidate the role of this enzyme in the central nervous system. +3 more findings

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Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD

36/100 ✓ Peer-reviewed Genetics Neurobiology of aging

Key finding: In AD hippocampus, peptidyl prolyl cis-trans isomerase, phosphoglycerate mutase 1, ubiquitin carboxyl terminal hydrolase 1, dihydropyrimidinase related protein-2 (DRP-2), carbonic anhydrase II, triose phosphate isomerase, alpha-enolase, and gamma-SNAP were identified as significantly oxidized protein with reduced enzyme activities relative to control hippocampus. +1 more finding

• Brain Biology

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Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia

64/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: Vascular and inflammatory factors may play an important role in the pathogenesis of dementia. +3 more findings

• Risk Factors

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Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study

52/100 ✓ Peer-reviewed Brain scans and imaging Stroke

Key finding: DTI histograms may be used as an adjunct outcome measure in future therapeutic trials.

• Brain Scans
• Genetics

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Vulnerable populations at risk of potentially avoidable hospitalizations: the case of nursing home residents with Alzheimer's disease

36/100 ✓ Peer-reviewed Digital health tools American journal of Alzheimer's disease and other dementias

Key finding: The findings suggest that nursing home residents with ADRD are more likely to be hospitalized for certain ACS conditions, including gastroenteritis and kidney/ urinary tract infections. +1 more finding

• Care Services

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Curcumin: getting back to the roots

36/100 ✓ Peer-reviewed Costs and economics Annals of the New York Academy of Sciences

Key finding: Modern science has revealed that curcumin mediates its effects by modulation of several important molecular targets, including transcription factors (e.g., NF-kappaB, AP-1, Egr-1, beta-catenin, and PPAR-gamma), enzymes (e.g., COX2, 5-LOX, iNOS, and hemeoxygenase-1), cell cycle proteins (e.g., cyclin D1 and p21), cytokines (e.g., TNF, IL-1, IL-6, and chemokines), receptors (e.g., EGFR and HER2), and cell surface adhesion molecules.

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The interplay of neurotransmitters in Alzheimer's disease

36/100 ✓ Peer-reviewed Treatments CNS spectrums

Key finding: The sustained low-level activation of NMDA receptors, which are pivotal in learning and memory, may result from deficiencies in glutamate reuptake by astroglial cells in the synaptic cleft. +1 more finding

• Treatments

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Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain

36/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Unexpectedly, we saw no significant retention of PIB in this model even at 12 months of age when amyloid deposition in the PS1/APP mouse typically exceeds that seen in AD. +1 more finding

• Brain Scans
• Brain Biology

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Benefits of rivastigmine on attention in dementia associated with Parkinson disease

77/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology

Key finding: In a 24-week, randomized, double-blind, placebo-controlled, multicenter study of rivastigmine, 487 patients with dementia associated with Parkinson disease underwent assessment of attention on the Cognitive Drug Research computerized cognitive assessment system before dosing and 16 and 24 weeks later. +1 more finding

• Treatments
• Clinical Trials
• Other Dementias

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Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory

57/100 ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

Key finding: Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions. +1 more finding

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Neuropathology of dementia in Parkinson's disease: a prospective, community-based study

47/100 ✓ Peer-reviewed Clinical safety Annals of neurology

Key finding: The Lewy body score and Braak and Braak stage were significantly associated with the rate of cognitive decline, but only the Lewy body score was associated with the rate of cognitive decline in the univariate analyses. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Progressive neurodegeneration in C. elegans model of tauopathy

36/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of disease

Key finding: Whereas the worm expressing wild-type tau showed a small decrease in the touch response across the lifespan, the worm expressing mutant tau displayed a large and progressive decrease. +4 more findings

• Brain Biology

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Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia

52/100 ✓ Peer-reviewed Disease mechanisms Archives of neurology

Key finding: Patients with Alzheimer disease have reduced levels of sRAGE in plasma compared with patients with vascular dementia and controls. +1 more finding

• Other Dementias

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The Alzheimer's Disease Neuroimaging Initiative

54/100 ✓ Peer-reviewed Long-term cohort studies Neuroimaging Clinics of North America

This text describes the Alzheimer's Disease Neuroimaging Initiative, which addresses the growing incidence and socioeconomic impact of Alzheimer's disease as life expectancy increases.

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Depression, Dementia, or Pseudodementia?

29/100 ✓ Peer-reviewed Risk factors CNS Spectrums

Key finding: Her husband indicated that she rarely drinks alcohol.

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