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Frontotemporal dementia
Neary D, Snowden J, Mann D.. The Lancet. Neurology, 2005-11-01
Topic: Risk, prevention and care in population studies
Frontotemporal dementia (FTD) is a focal clinical syndrome characterised by profound changes in personality and social conduct and associated with circumscribed degeneration of the prefrontal and anterior temporal cortex. Onset is typically in the middle years of life and survival is about 8 years. The presence of microtubule-associated-protein-tau-based pathological features in some patients and the discovery, in some familial cases, of mutations in the tau gene links FTD to other forms of tauopathy, such as progressive supranuclear palsy and corticobasal degeneration. However, more than half of all patients with FTD, including some with a strong family history, show no apparent abnormality in the tau gene or protein, indicating pathological and aetiological heterogeneity. FTD provides a challenge both for clinical management and for theoretical understanding of its neurobiological substrate.
Key findings
- Frontotemporal dementia (FTD) is a focal clinical syndrome characterised by profound changes in personality and social conduct and associated with circumscribed degeneration of the prefrontal and anterior temporal cortex.
Why it matters
This review describes frontotemporal dementia as a focal clinical syndrome with circumscribed degeneration of the prefrontal and anterior temporal cortex and notes that many cases show no apparent tau abnormality. It is a review, not a treatment, cure or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 48/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet. Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 525 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.8 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 4 / 6 | Cited 16.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 19 other studies in this library |
| Still being cited | 2 / 4 | Cited 32 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author David M. A. Mann: h-index 74 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Salford Royal Hospital: institution h-index 331 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16239184) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Neary, D., Snowden, J., & Mann, D. (2005). Frontotemporal dementia. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(05)70223-4
Vancouver
Neary D, Snowden J, Mann D. Frontotemporal dementia. The Lancet. Neurology. 2005. doi:10.1016/s1474-4422(05)70223-4. PMID: 16239184.
BibTeX
@article{neary2005-16239184,
author = {Neary, D. and Snowden, J. and Mann, D.},
title = {{Frontotemporal dementia}},
journal = {The Lancet. Neurology},
year = {2005},
doi = {10.1016/s1474-4422(05)70223-4},
pmid = {16239184},
url = {https://doi.org/10.1016/s1474-4422(05)70223-4}
}
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