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Excessive daytime sleepiness and subsequent development of Parkinson disease
Abbott RD, Ross GW, White LR, Tanner CM, Masaki KH, Nelson JS, Curb JD, Petrovitch H.. Neurology, 2005-11-01
Topic: Risk, prevention and care in population studies
Objective To determine if excessive daytime sleepiness (EDS) can predate future Parkinson disease (PD). Methods EDS was assessed in 3,078 men aged 71 to 93 years in the Honolulu-Asia Aging Study from 1991 to 1993. All were free of prevalent PD and dementia. Follow-up for incident PD was based on three repeat neurologic assessments from 1994 to 2001. Results During the course of follow-up, 43 men developed PD (19.9/10,000 person-years). After age adjustment, there was more than a threefold excess in the risk of PD in men with EDS vs men without EDS (55.3 vs 17.0/10,000 person-years; odds ratio [OR] = 3.3; 95% CI = 1.4 to 7.0; p = 0.004). Additional adjustment for insomnia, cognitive function, depressed mood, midlife cigarette smoking and coffee drinking, and other factors failed to alter the association between EDS and PD (OR = 2.8; 95% CI = 1.1 to 6.4; p = 0.014). Other sleep related features such as insomnia, daytime napping, early morning grogginess, and frequent nocturnal awakening showed little relation with the risk of PD. Conclusions Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease.
Key findings
- Results During the course of follow-up, 43 men developed PD (19.9/10,000 person-years).
- Conclusions Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease.
Why it matters
In 3,078 older men, excessive daytime sleepiness was linked to about a threefold higher risk of later developing Parkinson disease. This concerns Parkinson disease risk and does not address treating, curing or preventing Alzheimer's disease.
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Study details
- Effect sizeOR = 2.8
- Evidence strengthLow
How this study scored 53/100
Published in a leading specialty journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 443 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 19.3 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 4 / 6 | Cited 8.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 52 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Helen Petrovitch: h-index 71 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Virginia: institution h-index 1,118 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16275833) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Abbott, R. D., Ross, G. W., White, L. R., Tanner, C. M., Masaki, K. H., Nelson, J. S., et al. (2005). Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology. https://doi.org/10.1212/01.wnl.0000183056.89590.0d
Vancouver
Abbott RD, Ross GW, White LR, Tanner CM, Masaki KH, Nelson JS, et al. Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology. 2005. doi:10.1212/01.wnl.0000183056.89590.0d. PMID: 16275833.
BibTeX
@article{abbott2005-16275833,
author = {Abbott, R. D. and Ross, G. W. and White, L. R. and Tanner, C. M. and Masaki, K. H. and Nelson, J. S. and Curb, J. D. and Petrovitch, H.},
title = {{Excessive daytime sleepiness and subsequent development of Parkinson disease}},
journal = {Neurology},
year = {2005},
doi = {10.1212/01.wnl.0000183056.89590.0d},
pmid = {16275833},
url = {https://doi.org/10.1212/01.wnl.0000183056.89590.0d}
}
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