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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,826–25,850 of 27,380 studies, newest first · page 1034 of 1096.

January 1999 21

  1. 1999-01-01

    Criteria for enrolling dementia patients in hospice: a replication

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Non-ordinal patients lived significantly longer at a mean of 10.9 months (p < .01), and and the minority (30 percent) died within six months. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 1999-01-01

    Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates

    ✓ Peer-reviewed Inflammation and the immune system Journal of virology

    Key finding: To characterize human adult microglial chemokine receptors, we analyzed the expression and calcium signaling of CCR5, CCR3, and CXCR4 and their roles in HIV entry. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1999-01-01

    A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroimmunology

    Key finding: A beta plays a role in the pathology of AD by directly causing neuronal cytotoxicity and stimulating microglia to secrete cytokines and reactive oxygen species (ROS) which also damage neurons. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1999-01-01

    Clinical features of Alzheimer's disease

    ✓ Peer-reviewed Brain tissue and pathology European archives of psychiatry and clinical neuroscience

    Key finding: For a clinical diagnosis of dementia, cognitive impairment has to be severe enough to compromise the activities of daily living. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1999-01-01

    Neuropathology of Alzheimer's disease: what is new since A. Alzheimer?

    ✓ Peer-reviewed Brain tissue and pathology European archives of psychiatry and clinical neuroscience

    Key finding: These intraneuronal changes take the form of neurofibrillary tangles and neuropil threads. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1999-01-01

    Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Neuroscience letters

    Key finding: Levels of CSF tau were measured in 17 patients with Alzheimer's disease and 23 patients with frontotemporal dementia, and were compared to age-matched healthy controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1999-01-01

    TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs

    ✓ Peer-reviewed Risk genes beyond APOE FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: Multiple epidemiological studies also suggest that patients taking anti-inflammatory drugs have a decreased risk of developing AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1999-01-01

    Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

    ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Abeta, derived by proteolytic cleavage from the beta-amyloid precursor protein (betaAPP), is normally secreted. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 1999-01-01

    Dementia in Down syndrome. Untangling the threads

    ✓ Peer-reviewed Down syndrome and Alzheimer's Australian family physician

    Key finding: Despite frequent neuropathological findings, the prevalence of dementia in people with Down syndrome is thought to be no higher than in the general population. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 1999-01-01

    Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

    Key finding: Frameshifts are caused by dinucleotide deletions in GAGAG motifs in messenger RNA and are now thought to be the result of unfaithful transcription of normal DNA by a novel process termed "molecular misreading".

    Full summary, score breakdown and related studies → Original source

  11. 1999-01-01

    Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

    Key finding: NAIP-like immunoreactivity was determined in four different regions of cerebral cortex and cerebellum in 9 adult DS patients with Alzheimer-like neuropathologic lesions, 9 Alzheimer disease (AD) patients as compared to 9 controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 1999-01-01

    Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer's disease

    ✓ Peer-reviewed Down syndrome and Alzheimer's Life sciences

    Key finding: Thyroid hormone abnormalities are strongly associated with Down Syndrome (DS) with elevated thyroid stimulating hormone (TSH) levels as the most consistent finding. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 1999-01-01

    Serotonin (5-HT) in brains of adult patients with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

    Key finding: In DS, 5-HT was found to be age-dependent significantly decreased in caudate nucleus by 60% (DS: mean +/- SD 58.6 +/- 28.2 vs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 1999-01-01

    Molecular abnormalities of the brain in Down syndrome: relevance to Alzheimer's neurodegeneration

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neural transmission. Supplementum

    Key finding: Down syndrome is associated with developmental abnormalities of the central nervous system that result in mental retardation and age-dependent Alzheimer-type neurodegeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 1999-01-01

    Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

    Key finding: Upregulation of p53 and APO-1/Fas (CD95) precedes apoptosis in many cell types, and a potential role for these molecules has already been demonstrated in Alzheimer's disease (AD) and several other neurodegenerative diseases. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 1999-01-01

    Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia

    ✓ Peer-reviewed How common it is Neurology

    Key finding: Contrary to previous reports, head trauma was not a risk factor for AD, and smoking did not protect against AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 1999-01-01

    Physical aggression in dementia patients and its relationship to depression

    ✓ Peer-reviewed Disparities The American journal of psychiatry

    Key finding: A substantial minority of patients with dementia exhibit physically aggressive behavior, and this aggression is strongly linked with the presence of depressive symptoms. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 1999-01-01

    Risk factors for hip fracture in men from southern Europe: the MEDOS study. Mediterranean Osteoporosis Study

    ✓ Peer-reviewed Prevention and risk Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    Key finding: Significant risk factors identified by univariate analysis included low body mass index (BMI), low sunlight exposure, a low degree of recreational physical activity, low consumption of milk and cheese, and a poor mental score. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 1999-01-01

    Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison

    ✓ Peer-reviewed Biomarkers Experimental gerontology

    Key finding: However, the catecholaminergic cells in the frontal cortex of the AD patients revealed a significant decrease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 1999-01-01

    Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Journal of neuroscience research

    Key finding: An individual variation in GLAST and GLT levels was found, but no significant correlation with Alzheimer's disease, except for a 14% lower ratio of N-terminal to central GLT immunoreactivity (P < 0.04). +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 1999-01-01

    Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia

    ✓ Peer-reviewed Biomarkers Journal of neuropathology and experimental neurology

    Key finding: Neuropathologic examination indicated that among 30 patients with a clinical history of severe dementia, 22 had Braak and Braak stage V-VI Alzheimer disease, 3 had combined Alzheimer and Parkinson disease, 3 had Pick disease and 2 had severe hippocampal sclerosis. +1 more finding

    Full summary, score breakdown and related studies → Original source

December 1998 4

  1. 1998-12-18

    Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains

    ✓ Peer-reviewed Drug development Neuroscience letters

    Key finding: The Gallyas-Braak silver impregnation method revealed neurons containing well-defined intraneuronal granules in both Alzheimer's disease and normal control brains. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 1998-12-01

    Behavioral vs drug treatment for urge urinary incontinence in older women: a randomized controlled trial

    ✓ Peer-reviewed Clinical trials JAMA

    Key finding: Behavioral treatment is a safe and effective conservative intervention that should be made more readily available to patients as a first-line treatment for urge and mixed incontinence. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 1998-12-01

    Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology

    ✓ Peer-reviewed Treatments Drug safety

    Key finding: Tacrine is associated with hepatotoxicity while other cholinesterase inhibitors seem devoid this adverse effect.

    Full summary, score breakdown and related studies → Original source

  4. 1998-12-01

    Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: To investigate whether these receptors may have functions that go beyond ligand internalization, e.g. possible roles in cellular signaling, we searched for proteins that might interact with the cytoplasmic tails of the receptors. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →