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Hippocampal atrophy in Alzheimer disease: age matters
van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM.. Neurology, 2006-01-01
Topic: Amyloid, tau and blood-test diagnosis
Hippocampal atrophy is a marker of Alzheimer disease (AD). It remains unclear whether this holds true for younger patients as well. Hippocampal volume was measured on MRI scans of 103 clinically diagnosed AD patients and 73 controls (aged 51 to 85 years). Aging and AD were independently associated with smaller hippocampal volume. Both young and old AD patients have hippocampal atrophy abnormal for age. Age-dependent criteria for hippocampal atrophy, suggestive of AD, are needed.
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APA 7th
van de Pol, L. A., Hensel, A., Barkhof, F., Gertz, H. J., Scheltens, P., & van der Flier, W. M. (2006). Hippocampal atrophy in Alzheimer disease: age matters. Neurology. https://doi.org/10.1212/01.wnl.0000194240.47892.4d
Vancouver
van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM. Hippocampal atrophy in Alzheimer disease: age matters. Neurology. 2006. doi:10.1212/01.wnl.0000194240.47892.4d. PMID: 16434661.
BibTeX
@article{vandepol2006-16434661,
author = {van de Pol, L. A. and Hensel, A. and Barkhof, F. and Gertz, H. J. and Scheltens, P. and van der Flier, W. M.},
title = {{Hippocampal atrophy in Alzheimer disease: age matters}},
journal = {Neurology},
year = {2006},
doi = {10.1212/01.wnl.0000194240.47892.4d},
pmid = {16434661},
url = {https://doi.org/10.1212/01.wnl.0000194240.47892.4d}
}
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Key findings
- Aging and AD were independently associated with smaller hippocampal volume.
Why it matters
In 103 clinically diagnosed Alzheimer's patients and 73 controls, both aging and Alzheimer's disease were independently associated with smaller hippocampal volume, and both young and old Alzheimer's patients had hippocampal atrophy abnormal for their age. This supports hippocampal volume as a marker of Alzheimer's across ages and suggests age-dependent criteria are needed, but it does not address treatment or prevention.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 151 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.9 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 6.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Wiesje M. van der Flier: h-index 132 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Amsterdam UMC Location Vrije Universiteit Amsterdam: institution h-index 938 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16434661) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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