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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,751–25,775 of 27,380 studies, newest first · page 1031 of 1096.

May 1999 8

  1. 1999-05-01

    Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders

    ✓ Peer-reviewed Disease mechanisms Brain research. Molecular brain research

    Key finding: These results suggest a phylogenetic descent of splicing paradigms, which can be matched with known phylogenetic concepts based on morphological and molecular genetical studies.

    Full summary, score breakdown and related studies → Original source

  2. 1999-05-01

    Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

    ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Here we show that missense, silent, and intronic tau mutations can increase or decrease splicing of tau exon 10 (E10) by acting on 3 different cis-acting regulatory elements. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1999-05-01

    Neuronal loss and beta-amyloid removal in the amygdala of people with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

    Key finding: The correlation between the decrease in the number of neurons and the decrease in the amount of A beta indicates that amyloid deposition is associated with neurons and that loss of neurons causes decrease in A beta deposition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1999-05-01

    The effects of donepezil in Alzheimer's disease - results from a multinational trial

    ✓ Peer-reviewed Treatments Dementia and geriatric cognitive disorders

    Key finding: Statistically significant improvements in cognitive and global function were observed, as evaluated by ADAS-cog and CIBIC plus, respectively, in both the 5 and 10 mg/day donepezil groups, compared with placebo. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1999-05-01

    Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series

    ✓ Peer-reviewed Getting a diagnosis Journal of the American Geriatrics Society

    Key finding: This study of a large series of community-based incident dementia cases provides a way of judging the adequacy of currently available clinical diagnostic criteria. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 1999-05-01

    Double-blind, randomized, placebo-controlled clinical trial on the efficacy and tolerability of a physostigmine patch in patients with senile dementia of the Alzheimer type

    ✓ Peer-reviewed Treatments Pharmacopsychiatry

    Key finding: In order to overcome the problems associated with the oral and intravenous application of physostigmine, and to improve patients' compliance, a transdermal therapeutic system was developed. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1999-05-01

    Selegiline in the treatment of Alzheimer's disease: a long-term randomized placebo-controlled trial. Czech and Slovak Senile Dementia of Alzheimer Type Study Group

    ✓ Peer-reviewed Treatments Journal of psychiatry & neuroscience : JPN

    Key finding: Selegiline has a long-term beneficial effect in Alzheimer's disease on memory modalities that reflect the function of the prefrontal areas of the brain, which are rich in dopamine receptors. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1999-05-01

    Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF

    ✓ Peer-reviewed Genetics Neurology

    Key finding: The combined measure of CSF Abeta42 and tau meets the requirements for clinical use in discriminating AD from normal aging and specific neurologic disorders. +3 more findings

    Full summary, score breakdown and related studies → Original source

April 1999 17

  1. 1999-04-01

    Increased Peroxynitrite Activity in AIDS Dementia Complex: Implications for the Neuropathogenesis of HIV-1 Infection

    ✓ Peer-reviewed Biomarkers The Journal of Immunology

    Key finding: RNA expression of IL-1beta, IL-10, inducible nitric oxide synthase, and superoxide dismutase (SOD) was found to be significantly higher in demented compared with nondemented patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 1999-04-01

    Utility scores for chronic conditions in a community-dwelling population

    ✓ Peer-reviewed Disease mechanisms PharmacoEconomics

    Key finding: This study provides health economists, researchers and policy-makers with a reference for health utilities of various chronic conditions, different age groups, gender and comorbidities. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 1999-04-01

    Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

    ✓ Peer-reviewed Risk factors Nature medicine

    Key finding: Furthermore, clinical evidence showing an association between higher educational attainment and reduced risk of Alzheimer and Parkinson-related dementia indicates that a stimulating environment has positive effects on cerebral health that may provide some resilience to cerebral insults.

    Full summary, score breakdown and related studies → Original source

  4. 1999-04-01

    Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: The results of the cost-effectiveness model presented here suggest that donepezil may be cost-effective but additional controlled data on long-term drug efficacy are needed. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1999-04-01

    Presenilin is required for activity and nuclear access of Notch in Drosophila

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Key finding: Presenilins are membrane proteins with multiple transmembrane domains that are thought to contribute to the development of Alzheimer's disease by affecting the processing of beta-amyloid precursor protein. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1999-04-01

    A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Key finding: A deficiency in presenilin-1 (PS1) inhibits processing of APP by gamma-secretase in mammalian cells, and genetic interactions between Notch and PS1 homologues in Caenorhabditis elegans indicate that the presenilins may modulate the Notch signalling pathway.

    Full summary, score breakdown and related studies → Original source

  7. 1999-04-01

    Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

    ✓ Peer-reviewed Biomarkers Neuroscience

    Key finding: Mutations in the beta-amyloid precursor protein are strongly associated with some cases of familial Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1999-04-01

    MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia

    ✓ Peer-reviewed Hippocampus size on brain scans The American journal of psychiatry

    Key finding: Hippocampal volume, while disproportionately small for brain size in individuals with Down's syndrome, remains fairly constant through the fifth decade of life in those without dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 1999-04-01

    Hippocampal volume in patients with alcohol dependence

    ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

    Key finding: In chronic alcoholism, the reduction of hippocampal volume is proportional to the reduction of the brain volume. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 1999-04-01

    Does stress damage the brain?

    ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

    Key finding: Studies in animals showed that stress results in damage to the hippocampus, a brain area involved in learning and memory, with associated memory deficits.

    Full summary, score breakdown and related studies → Original source

  11. 1999-04-01

    The neuropathology of schizophrenia. A critical review of the data and their interpretation

    ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology

    Key finding: Functional imaging data indicate that the pathophysiology of schizophrenia reflects aberrant activity in, and integration of, the components of distributed circuits involving the prefrontal cortex, hippocampus and certain subcortical structures.

    Full summary, score breakdown and related studies → Original source

  12. 1999-04-01

    Confusional state in stroke: relation to preexisting dementia, patient characteristics, and outcome

    ✓ Peer-reviewed Clinical safety Stroke

    Key finding: ACS occurs in one fourth of stroke patients older than 40 years. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 1999-04-01

    The General Medical Health Rating: a bedside global rating of medical comorbidity in patients with dementia

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: GMHR is a reliable, valid, global bedside measure of severity of general medical comorbidity for patients with dementia that can be used for clinical and research purposes.

    Full summary, score breakdown and related studies → Original source

  14. 1999-04-01

    Tau pathology in a family with dementia and a P301L mutation in tau

    ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology

    Key finding: Familial forms of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) have recently been associated with coding region and intronic mutations in the tau gene. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 1999-04-01

    Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

    ✓ Peer-reviewed Risk genes beyond APOE Nature

    Full summary, score breakdown and related studies → Original source

  16. 1999-04-01

    Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: During the period of longitudinal observation, which averaged 32.6 months, 27 of the 80 MCI patients became demented. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 1999-04-01

    Cholinergic markers in elderly patients with early signs of Alzheimer disease

    ✓ Peer-reviewed Brain tissue and pathology JAMA

    Key finding: A central tenet of Alzheimer disease (AD) is the loss of cortical cholinergic function and cholinergic markers in postmortem brain specimens. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →