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Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease
Alain R. Simard, Denis Soulet, Genevíève Gowing, Jean-Pierre Julien, Serge Rivest. Neuron, 2006-02-01
Topic: Brain proteins, microglia and lab models
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Why it matters
Reports that microglia derived from bone marrow play a critical role in restricting senile plaque formation in Alzheimer's disease.
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 52 of the 95 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuron) |
| Journal's citation record | 4 / 4 | Neuron: journal h-index 689 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,269 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 57.7 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 6 / 6 | Cited 46.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 91 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Serge Rivest: h-index 94 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Université Laval: institution h-index 823 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16476660) |
| Free to read | 2 / 2 | Free to read |
| Points | 52 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 52 of the 95 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006). Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease. Neuron. https://doi.org/10.1016/j.neuron.2006.01.022
Vancouver
Simard AR, Soulet D, Gowing G, Julien J.-P, Rivest S. Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease. Neuron. 2006. doi:10.1016/j.neuron.2006.01.022. PMID: 16476660.
BibTeX
@article{simard2006-16476660,
author = {Simard, Alain R. and Soulet, Denis and Gowing, Genevíève and Julien, Jean-Pierre and Rivest, Serge},
title = {{Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease}},
journal = {Neuron},
year = {2006},
doi = {10.1016/j.neuron.2006.01.022},
pmid = {16476660},
url = {https://doi.org/10.1016/j.neuron.2006.01.022}
}