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BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls
Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, Soekadar S, Richartz E et al.. Journal of psychiatric research, 2006-03-22
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) are common forms of dementia in the elderly. Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD. BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain.
Key findings
- Recent findings have suggested an involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of AD.
- BDNF is an endogenous protein involved in the maintenance of neuronal function, synaptic plasticity and structural integrity in the adult brain.
- BDNF serum and cerebrospinal fluid (CSF) concentrations were assessed by a sensitive ELISA in 27 AD patients in comparison to 9 NPH patients and 28 age-matched healthy controls (10 CSF samples).
- We found a significant decrease of BDNF serum concentration in AD (18.6ng/ml) and NPH patients (18.1ng/ml) as compared to healthy controls (21.3ng/ml; p=0.041/p=0.017).
Why it matters
This study measured BDNF concentrations in serum and cerebrospinal fluid in 27 Alzheimer's disease patients, 9 patients with normal pressure hydrocephalus and 28 age-matched healthy controls, finding a significant decrease of BDNF. It only examines a possible marker of the disease and does not test any treatment, cure or prevention.
Study details
- Effect size29.6%; 11.1%
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of psychiatric research) |
| Journal's citation record | 2 / 4 | Journal of Psychiatric Research: journal h-index 220 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 271 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.9 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 3 / 6 | Cited 4.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 2 / 4 | Cited 29 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Klaus J. Schott: h-index 19 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Tübingen: institution h-index 940 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16554070) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Maetzler, W., Wittorf, A., et al. (2007). BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. Journal of psychiatric research. https://doi.org/10.1016/j.jpsychires.2006.01.014
Vancouver
Laske C, Stransky E, Leyhe T, Eschweiler GW, Maetzler W, Wittorf A, et al. BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. Journal of psychiatric research. 2007. doi:10.1016/j.jpsychires.2006.01.014. PMID: 16554070.
BibTeX
@article{laske2007-16554070,
author = {Laske, C. and Stransky, E. and Leyhe, T. and Eschweiler, G. W. and Maetzler, W. and Wittorf, A. and Soekadar, S. and Richartz, E. and others},
title = {{BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls}},
journal = {Journal of psychiatric research},
year = {2007},
doi = {10.1016/j.jpsychires.2006.01.014},
pmid = {16554070},
url = {https://doi.org/10.1016/j.jpsychires.2006.01.014}
}
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