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Interleukin-1 mediates Alzheimer and Lewy body pathologies
Griffin WS, Liu L, Li Y, Mrak RE, Barger SW.. Journal of neuroinflammation, 2006-03-16
Topic: Amyloid, tau and blood-test diagnosis
Background Clinical and neuropathological overlap between Alzheimer's (AD) and Parkinson's disease (PD) is now well recognized. Such cases of concurrent AD and Lewy body disease (AD/LBD) show neuropathological changes that include Lewy bodies (alpha-synuclein aggregates), neuritic amyloid plaques, and neurofibrillary tangles (hyperphosphorylated tau aggregates). The co-occurrence of these clinical and neuropathological changes suggests shared pathogenic mechanisms in these diseases, previously assumed to be distinct.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Griffin, W. S., Liu, L., Li, Y., Mrak, R. E., & Barger, S. W. (2006). Interleukin-1 mediates Alzheimer and Lewy body pathologies. Journal of neuroinflammation. https://doi.org/10.1186/1742-2094-3-5
Vancouver
Griffin WS, Liu L, Li Y, Mrak RE, Barger SW. Interleukin-1 mediates Alzheimer and Lewy body pathologies. Journal of neuroinflammation. 2006. doi:10.1186/1742-2094-3-5. PMID: 16542445.
BibTeX
@article{griffin2006-16542445,
author = {Griffin, W. S. and Liu, L. and Li, Y. and Mrak, R. E. and Barger, S. W.},
title = {{Interleukin-1 mediates Alzheimer and Lewy body pathologies}},
journal = {Journal of neuroinflammation},
year = {2006},
doi = {10.1186/1742-2094-3-5},
pmid = {16542445},
url = {https://doi.org/10.1186/1742-2094-3-5}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Such cases of concurrent AD and Lewy body disease (AD/LBD) show neuropathological changes that include Lewy bodies (alpha-synuclein aggregates), neuritic amyloid plaques, and neurofibrillary tangles (hyperphosphorylated tau aggregates).
- The co-occurrence of these clinical and neuropathological changes suggests shared pathogenic mechanisms in these diseases, previously assumed to be distinct.
- Glial activation, with overexpression of interleukin-1 (IL-1) and other proinflammatory cytokines, has been increasingly implicated in the pathogenesis of both AD and PD.
- Methods Rat primary cultures of microglia and cortical neurons were cultured either separately or as mixed cultures.
Why it matters
This work links glial activation and overexpression of the inflammatory molecule interleukin-1 to the brain changes seen in people with both Alzheimer's disease and Lewy body disease. It suggests shared inflammatory mechanisms between the two conditions, but it does not report a treatment that alters the course of either disease.
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Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuroinflammation) |
| Journal's citation record | 2 / 4 | Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 261 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.9 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 7.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 10 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Steven W. Barger: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | United States Department of Veterans Affairs: institution h-index 735 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16542445) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1186/1742-2094-3-5
- PubMed: 16542445
- Original source →
- Free full text: Journal of Neuroinflammation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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