Newest studies

CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson disease

63/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Cognitive decline associated with Parkinson disease (PD) is common and highly disabling. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Making decisions for people with dementia who lack capacity: qualitative study of family carers in UK

52/100 ✓ Peer-reviewed Caregiving BMJ (Clinical research ed.)

Key finding: The following strategies helped with implementation of decisions: introducing change slowly; organising legal changes for the carer as well as the patient; involving a professional to persuade the patient to accept services; and emphasising that services optimised, not impeded, independence.

• Caregiving

Full summary, score breakdown and related studies → Original source

New diagnostic EEG markers of the Alzheimer's disease using visibility graph

40/100 ✓ Peer-reviewed Digital health tools Journal of neural transmission (Vienna, Austria : 1996)

Key finding: Two methods are employed for computation of complexity of the VGs: one based on the power of scale-freeness of a graph structure and the other based on the maximum eigenvalue of the adjacency matrix of a graph. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Cognitive intervention in Alzheimer disease

44/100 ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology

Key finding: Data suggest that specifically designed cognitive interventions could impart therapeutic benefits to patients with AD that are associated with substantial biological changes within the brain. +1 more finding

• Brain Scans
• Treatments

Full summary, score breakdown and related studies → Original source

Accelerated progression from mild cognitive impairment to dementia in people with diabetes

57/100 ✓ Peer-reviewed Mild cognitive impairment Diabetes

Key finding: Diabetes and pre-diabetes substantially accelerate the progression from MCI to dementia, and anticipate dementia occurrence by more than 3 years in people with MCI. +2 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Olfactory deficit detected by fMRI in early Alzheimer's disease

45/100 ✓ Peer-reviewed Cognitive tests and assessment Brain research

Key finding: Currently, it is unknown whether AD-related alterations in central olfactory system neural activity, as measured by functional magnetic resonance imaging (fMRI), are detectable beyond those observed in healthy elderly. +3 more findings

Full summary, score breakdown and related studies → Original source

Therapeutic potential of the original incretin hormone glucose-dependent insulinotropic polypeptide: diabetes, obesity, osteoporosis and Alzheimer's disease?

36/100 ✓ Peer-reviewed Drug development Expert Opinion on Investigational Drugs

Key finding: It is worthwhile to refocus on this important and somewhat neglected incretin hormone. +4 more findings

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

36/100 ✓ Peer-reviewed Drug development Pharmacology & therapeutics

Key finding: Although lithium's therapeutic mechanisms are not fully understood, substantial in vitro and in vivo evidence suggests that it has neuroprotective/neurotrophic properties against various insults, and considerable clinical potential for the treatment of several neurodegenerative conditions. +2 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Chaperone-mediated autophagy markers in Parkinson disease brains

47/100 ✓ Peer-reviewed Lewy body dementia Archives of neurology

Key finding: These findings suggest that there is reduced chaperone-mediated autophagy activity in the PD brain, provide evidence for the role of autophagy in PD pathogenesis and Lewy body formation, and suggest that this pathway may be a suitable therapeutic target in PD. +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

50/100 ✓ Peer-reviewed Genetics Archives of neurology

Key finding: We confirm in a completely independent data set that CR1, CLU, and PICALM are AD susceptibility loci in European ancestry populations. +4 more findings

• Genetics
• Health Equity

Full summary, score breakdown and related studies → Original source

A meta-analysis of cytokines in Alzheimer's disease

66/100 ✓ Peer-reviewed Tau biomarkers Biological psychiatry

Key finding: These results strengthen the clinical evidence that AD is accompanied by an inflammatory response, particularly higher peripheral concentrations of IL-6, TNF-α, IL-1β, TGF-β, IL-12 and IL-18 and higher CSF concentrations of TGF-β. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Assessment of cognitive insight: a qualitative review

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Schizophrenia bulletin

Key finding: Several independent groups have demonstrated that the BCIS is reliable, demonstrates convergent and construct validity, and distinguishes patients with psychosis from healthy controls and patients without psychosis.

Full summary, score breakdown and related studies → Original source

The contribution of chronic diseases to the prevalence of dependence among older people in Latin America, China and India: a 10/66 Dementia Research Group population-based survey

64/100 ✓ Peer-reviewed Disparities BMC geriatrics

Key finding: The demographic and health transitions will lead to large and rapid increases in the numbers of dependent older people particularly in middle income countries (MIC). +1 more finding

• Health Equity

Full summary, score breakdown and related studies → Original source

Neuropsychiatric symptoms underlying caregiver stress and insight in Alzheimer's disease

38/100 ✓ Peer-reviewed Caregiving Dementia and geriatric cognitive disorders

Key finding: Psychotic/behavioral, depressive and minimally symptomatic clusters differed for caregiver burden and lack of insight. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Survival of people with clinical diagnosis of dementia in primary care: cohort study

66/100 ✓ Peer-reviewed Caregiving BMJ (Clinical research ed.)

Key finding: Median survival was much lower than in screened populations. +2 more findings

• Diagnosis
• Care Services

Full summary, score breakdown and related studies → Original source

Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease

60/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

Key finding: We found unidirectional, specific sequential relationships between: (i) baseline hippocampal atrophy and both cingulum bundle (r = 0.70; P = 3 × 10⁻³) and uncinate fasciculus (r = 0.75; P = 7 × 10⁻⁴) rate of atrophy; (ii) baseline cingulum bundle atrophy and rate of decline of posterior (r = 0.72; P = 2 × 10⁻³); and anterior (r = 0.74; P = 1 × 10⁻³) cingulate metabolism; and (iii) baseline uncinate white matter atrophy and subgenual metabolism rate of change (r = 0.65; P = 6 × 10⁻³). +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors

70/100 ✓ Peer-reviewed Prevention and risk BMJ (Clinical research ed.)

Key finding: Increasing crystallised intelligence and fruit and vegetable consumption and eliminating depression and diabetes are likely to have the biggest impact on reducing the incidence of dementia, outweighing even the effect of removing the principal known genetic risk factor. +1 more finding

• Risk Factors
• Prevention
• Genetics

Full summary, score breakdown and related studies → Original source

Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease

38/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

Key finding: Significant increase in PIB retention as well as decrease in regional cerebral metabolic rate of glucose (rCMRglc) was observed at group level in the MCI patients while no significant change was observed in cognitive function. +3 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Cardiac index is associated with brain aging: the Framingham Heart Study

52/100 ✓ Peer-reviewed Brain scans and imaging Circulation

Key finding: Although observational data cannot establish causality, our findings are consistent with the hypothesis that decreasing cardiac function, even at normal cardiac index levels, is associated with accelerated brain aging. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases

38/100 ✓ Peer-reviewed Genetics Current opinion in lipidology

Key finding: The purpose of this review is to provide insights into recent advances in mechanisms linking apolipoprotein (apo) E isoforms to cardiovascular and neurological diseases. +2 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

36/100 ✓ Peer-reviewed Treatments The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We previously showed that memantine preferentially blocked neurotoxicity mediated by excessive NMDAR activity while relatively sparing normal neurotransmission, in part because of its uncompetitive antagonism with a fast off-rate. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Graph theoretical modeling of brain connectivity

36/100 ✓ Peer-reviewed Brain scans and imaging Current opinion in neurology

Key finding: In recent years, there has been an explosion of studies on network modeling of brain connectivity.

• Brain Scans

Full summary, score breakdown and related studies → Original source

MRI quantification of non-Gaussian water diffusion by kurtosis analysis

36/100 ✓ Peer-reviewed Brain scans and imaging NMR in biomedicine

Key finding: It is argued that the diffusional kurtosis is sensitive to diffusional heterogeneity and suggested that DKI may be useful for investigating ischemic stroke and neuropathologies, such as Alzheimer's disease and schizophrenia.

• Brain Scans

Full summary, score breakdown and related studies → Original source

The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia

43/100 ✓ Peer-reviewed Biomarkers Current Alzheimer research

Key finding: The CSF Abeta42/Abeta40 ratio improves differentiation of AD patients from VaD, DLB and non-AD dementia patients, when compared to Abeta42 alone, and is a more easily interpretable alternative to the combination of Abeta42, p-tau and t-tau when differentiating AD from either FTD or non-AD dementia. +3 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort

64/100 ✓ Peer-reviewed Vascular contributions Annals of neurology

Key finding: Atherosclerosis of the intracranial arteries is an independent and important risk factor for dementia, suggesting potentially reversible pathways unrelated to Alzheimer pathology and stroke through which vascular changes may influence dementia risk. +1 more finding

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source