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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 25,626–25,650 of 27,380 studies, newest first · page 1026 of 1096.

December 1999 12

  1. 1999-12-01

    Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

    ✓ Peer-reviewed Disease mechanisms Nature

    Full summary, score breakdown and related studies → Original source

  2. 1999-12-01

    Purification and cloning of amyloid precursor protein β-secretase from human brain

    ✓ Peer-reviewed Disease mechanisms Nature

    Full summary, score breakdown and related studies → Original source

  3. 1999-12-01

    Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Annals of Neurology

    Genetic evidence strongly supports the view that Abeta amyloid production is central to the cause of Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  4. 1999-12-01

    Head trauma and risk of dementia and Alzheimer's disease: The Rotterdam Study

    ✓ Peer-reviewed Long-term cohort studies Neurology

    Key finding: It has been suggested that the risk might be particularly increased for carriers of the APOE-epsilon4 allele. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1999-12-01

    Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: Eleven patients with idiopathic normal pressure hydrocephalus (NPH) were selected from an initial cohort of 43 patients. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1999-12-01

    Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type

    ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

    Key finding: We surveyed the medical records of outpatients meeting the NINCDS-ADRDA criteria for probable DAT who were able to complete the Cognitive Difficulties Scale (CDS) and had a close informant relative (IR) who could complete the family form of the same questionnaire. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 1999-12-01

    Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

    ✓ Peer-reviewed Risk genes beyond APOE The Biochemical journal

    Key finding: In the present study we show that adding copper to Chinese-hamster ovary (CHO) cells greatly reduced the levels of amyloid Abeta peptide (Abeta) both in parental CHO-K1 and in copper-resistant CHO-CUR3 cells, which have lower intracellular copper levels. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1999-12-01

    Presenilin 1 and alpha-1-antichymotrypsin polymorphisms in Down syndrome: no effect on the presence of dementia

    ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics

    Key finding: It has been suggested that polymorphisms at the genes for presenilin-1 (PS-1) and alpha-1-antichymotrypsin (ACT) confer an increased risk for AD in the general population, and therefore potentially to AD in people with DS. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 1999-12-01

    Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group

    ✓ Peer-reviewed How common it is Neurology

    Key finding: Compared with men, women have an increased risk for AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 1999-12-01

    Diabetes mellitus and the risk of dementia: The Rotterdam Study

    ✓ Peer-reviewed How common it is Neurology

    Key finding: The diabetes attributable risk for dementia of 8.8% suggests that diabetes may have contributed to the clinical syndrome in a substantial proportion of all dementia patients. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 1999-12-01

    Constructing Alzheimer's: narratives of lost identities, confusion and loneliness in old age

    ✓ Peer-reviewed Disparities Culture, medicine and psychiatry

    Key finding: Jones and other African-American, Chinese-American, Irish-American and Latino family caregivers in the Boston area. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 1999-12-01

    Dementia as the most common presentation of cortical-basal ganglionic degeneration

    ✓ Peer-reviewed Disparities Neurology

    Key finding: Dementia was the most common presentation of CBGD in this study. +1 more finding

    Full summary, score breakdown and related studies → Original source

November 1999 13

  1. 1999-11-23

    Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

    ✓ Peer-reviewed Vascular contributions Proceedings of the National Academy of Sciences

    Key finding: Here, we describe significant deposition of amyloid beta (Abeta) in the cerebral vasculature [cerebral amyloid angiopathy (CAA)] in aging APP23 mice that had striking similarities to that observed in human aging and Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 1999-11-01

    Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system

    ✓ Peer-reviewed Risk factors Pathology international

    Key finding: The genomic structure of ChAT is unique compared with other enzymes for neurotransmitters. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 1999-11-01

    Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression

    ✓ Peer-reviewed Prevention trials Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    Key finding: Physical activity and antidepressant treatment have each separately been of significant interest for the management of Alzheimer's disease (AD); particularly the behavioral problems associated with this dementing disorder. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 1999-11-01

    The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease

    ✓ Peer-reviewed Treatments Archives of neurology

    Key finding: Donepezil has psychotropic properties, and pretreatment behaviors help predict patients' responses to treatment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 1999-11-01

    Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings

    ✓ Peer-reviewed Brain scans and imaging Annals of the New York Academy of Sciences

    Key finding: It is characterized by a two-step mechanism: (1) An acute swelling, which primarily depends on the AMPA/kainate type of receptors, together with a disruption of the postsynaptic structures (type I afferent dendrites) resulting in a loss of function. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 1999-11-01

    Progression of falls in postmortem-confirmed parkinsonian disorders

    ✓ Peer-reviewed Clinical safety Movement disorders : official journal of the Movement Disorder Society

    Key finding: Significant group differences for latency, but not duration, of recurrent falls were observed.

    Full summary, score breakdown and related studies → Original source

  7. 1999-11-01

    The impact of HIV-related neuropsychological dysfunction on driving behavior. The HNRC Group

    ✓ Peer-reviewed Clinical safety Journal of the International Neuropsychological Society : JINS

    Key finding: HIV infection often results in neuropsychological (NP) impairment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 1999-11-01

    Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuropathology and experimental neurology

    Key finding: Epidemiological and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) slow the progression and delay the onset of Alzheimer disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 1999-11-01

    Hepatic encephalopathy: An update of pathophysiologic mechanisms

    ✓ Peer-reviewed Inflammation and the immune system Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

    Key finding: Although the precise pathophysiologic mechanisms responsible for HE are not completely understood, a deficit in neurotransmission rather than a primary deficit in cerebral energy metabolism appears to be involved. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 1999-11-01

    Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis

    ✓ Peer-reviewed Inflammation and the immune system The American journal of pathology

    Key finding: Such MPs originate, in measure, from a pool of circulating monocytes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 1999-11-01

    Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein

    ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

    Key finding: The aggregation of other synaptic proteins and synaptic vesicle-like structures in the alphaS- and betaS-labeled hilar dystrophic neurites suggests that synaptic dysfunction may result from these lesions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 1999-11-01

    Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform

    ✓ Peer-reviewed Lewy body dementia Neuron

    Key finding: Inclusions were present in cortical and brainstem neurons but were most abundant in spinal cord neurons, where they were associated with axon degeneration, diminished microtubules (MTs), and reduced axonal transport in ventral roots, as well as spinal cord gliosis and motor weakness.

    Full summary, score breakdown and related studies → Original source

  13. 1999-11-01

    Increased levels of tau-like protein in patients with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

    Key finding: The levels were detected in 22 of 40 DS persons and were significantly higher in DS than any other group (P < 0.0001).

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →