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Progression to dementia in clinical subtypes of mild cognitive impairment
Alexopoulos P, Grimmer T, Perneczky R, Domes G, Kurz A.. Dementia and geriatric cognitive disorders, 2006-05-04
Topic: Risk, prevention and care in population studies
Plain-language summary
Objective To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI). Patients A follow-up examination (average follow-up period: 3.49 +/- 2.2 years) was performed in 81 cognitively impaired, non-demented patients aged >55 years at baseline. Results 8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 of 8 patients with single non-memory MCI (37.5%) progressed to dementia. The clinical type of MCI is significantly associated with the likelihood of conversion to dementia. Discussion When the clinical syndrome of MCI evolves on a neurodegenerative basis, the multiple-domain type of MCI has a less favorable prognosis than the amnestic type and may represent a more advanced prodromal stage of dementia.
What this study adds
Evidence grade: Low
The record lists 32 participants. The type of mild cognitive impairment was significantly associated with likelihood of conversion, suggesting multiple-domain cases may be a more advanced stage, but no treatment was tested. Reported effect size: 37.5%.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Alexopoulos, P., Grimmer, T., Perneczky, R., Domes, G., & Kurz, A. (2006). Progression to dementia in clinical subtypes of mild cognitive impairment. Dementia and geriatric cognitive disorders. https://doi.org/10.1159/000093101
Vancouver
Alexopoulos P, Grimmer T, Perneczky R, Domes G, Kurz A. Progression to dementia in clinical subtypes of mild cognitive impairment. Dementia and geriatric cognitive disorders. 2006. doi:10.1159/000093101. PMID: 16679762.
BibTeX
@article{alexopoulos2006-16679762,
author = {Alexopoulos, P. and Grimmer, T. and Perneczky, R. and Domes, G. and Kurz, A.},
title = {{Progression to dementia in clinical subtypes of mild cognitive impairment}},
journal = {Dementia and geriatric cognitive disorders},
year = {2006},
doi = {10.1159/000093101},
pmid = {16679762},
url = {https://doi.org/10.1159/000093101}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results 8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 of 8 patients with single non-memory MCI (37.5%) progressed to dementia.
- The clinical type of MCI is significantly associated with the likelihood of conversion to dementia.
Why it matters
In 81 cognitively impaired but non-demented patients followed for an average of about 3.5 years, 25% of those with amnestic mild cognitive impairment, 54% with multiple-domain mild cognitive impairment, and 37.5% with single non-memory mild cognitive impairment progressed to dementia. The type of mild cognitive impairment was significantly associated with likelihood of conversion, suggesting multiple-domain cases may be a more advanced stage, but no treatment was tested.
Study details
- Participants32
- Effect size37.5%
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Dementia and geriatric cognitive disorders) |
| Journal's citation record | 1 / 4 | Dementia and Geriatric Cognitive Disorders: journal h-index 149 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 1 / 4 | 32 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 155 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.0 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 6.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Alexander Kurz: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Technical University of Munich: institution h-index 1,092 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16679762) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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