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Telemedicine, dementia and Down syndrome: implications for Alzheimer disease
Lott IT, Doran E, Walsh DM, Hill MA.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2006-07-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Background Individuals with Down syndrome (DS) who are at risk for dementia of the Alzheimer type (DAT) often live at sites remote from major medical centers. Telemedicine (TM) is a modality for providing medical care at remote locations but is underutilized for populations with Alzheimer disease (AD). Methods We studied the feasibility of using TM to evaluate symptoms of DAT in 90 individuals with DS. Dementia was assessed by an informant questionnaire, a direct measure of praxis, pathological reflexes on the neurologic examination, and the presence of cortical atrophy on a neuroimaging procedure. The neurologist was blinded to the scores on neuropsychological measures. Differences in average cognitive scores between a TM and traditional academic medical center-based clinic site (TAC) were tested using 2-way analysis variance with site and premorbid IQ as factors. Logistic regression was used to explore the relationship, in addition to the cognitive scores, of influences such as age, premorbid IQ, and site to the prediction of the physician's diagnosis of dementia. Results Components of the neurologic, imaging, and neuropsychological examinations differentiated subjects with and without DAT (p Conclusions It is feasible to make a diagnosis of DAT in DS by TM. This study supports the need for formal reliability and validity studies of TM preparatory to the consideration of this modality for use in clinical trials for AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lott, I. T., Doran, E., Walsh, D. M., & Hill, M. A. (2006). Telemedicine, dementia and Down syndrome: implications for Alzheimer disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1016/j.jalz.2006.04.001
Vancouver
Lott IT, Doran E, Walsh DM, Hill MA. Telemedicine, dementia and Down syndrome: implications for Alzheimer disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2006. doi:10.1016/j.jalz.2006.04.001. PMID: 19595881.
BibTeX
@article{lott2006-19595881,
author = {Lott, I. T. and Doran, E. and Walsh, D. M. and Hill, M. A.},
title = {{Telemedicine, dementia and Down syndrome: implications for Alzheimer disease}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2006},
doi = {10.1016/j.jalz.2006.04.001},
pmid = {19595881},
url = {https://doi.org/10.1016/j.jalz.2006.04.001}
}
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Key findings
- Results Components of the neurologic, imaging, and neuropsychological examinations differentiated subjects with and without DAT (p Conclusions It is feasible to make a diagnosis of DAT in DS by TM.
Why it matters
This study found that it is feasible to diagnose dementia of the Alzheimer type in people with Down syndrome using telemedicine, which could help those who live far from major medical centers. The authors call for formal reliability and validity studies of telemedicine before it is considered for wider use.
Study details
- Participants90
- Evidence strengthLow
How this study scored 36/100
Published in a leading specialty journal. Scored zero for study design and effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 1 / 4 | 90 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 1 / 2 | Blinded or placebo-controlled (as stated in the record) |
| Times cited | 3 / 7 | Cited 20 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.9 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Mary Ann Hill: h-index 17 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19595881) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 36 / 100 | — |
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