Newest studies

Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits

40/100 ✓ Peer-reviewed Disease mechanisms American Journal Of Pathology

Key finding: THY-Tau22 shows hyperphosphorylation of tau on several Alzheimer's disease-relevant tau epitopes (AT8, AT100, AT180, AT270, 12E8, tau-pSer396, and AP422), neurofibrillary tangle-like inclusions (Gallyas and MC1-positive) with rare ghost tangles and PHF-like filaments, as well as mild astrogliosis. +4 more findings

• Brain Biology

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Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment

48/100 ✓ Peer-reviewed Mild cognitive impairment Archives of general psychiatry

Key finding: Mild cognitively impaired patients with memory plus other cognitive domain deficits, rather than those with pure amnestic MCI, constituted the high-risk group.

• Early Stage

Full summary, score breakdown and related studies → Original source

Changes in motor subtype and risk for incident dementia in Parkinson's disease

36/100 ✓ Peer-reviewed Digital health tools Movement disorders : official journal of the Movement Disorder Society

Key finding: Transition from TD to PIGD subtype was associated with a more than threefold increase in the rate of Mini-Mental State Examination decline. +3 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

36/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Accumulation of APP across mitochondrial import channels, which varied with the severity of AD, inhibited the entry of nuclear-encoded cytochrome c oxidase subunits IV and Vb proteins, which was associated with decreased cytochrome c oxidase activity and increased levels of H2O2. +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Rural-urban differences in medical care for nursing home residents with severe dementia at the end of life

62/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Rural residence was also associated with lower risk of more than 10 days of hospitalization and ICU admission. +4 more findings

• End-of-Life Care
• Care Services
• Health Equity

Full summary, score breakdown and related studies → Original source

Antidepressant drug therapy and suicide in severely depressed children and adults: A case-control study

50/100 ✓ Peer-reviewed Clinical safety Archives of general psychiatry

Key finding: In these high-risk patients, antidepressant drug treatment does not seem to be related to suicide attempts and death in adults but might be related in children and adolescents. +3 more findings

• Treatments

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Reasons for admission to hospital for Parkinson's disease

36/100 ✓ Peer-reviewed Clinical safety Internal medicine journal

Key finding: PD was the secondary diagnosis in 645 admissions. +4 more findings

• Care Services
• Other Dementias

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Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12

53/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of Immunology

DAP12 is an ITAM-containing adapter that associates with receptors in myeloid and NK cells.

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Serum neurotrophins--a study on the time course and influencing factors in a large old age sample

49/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of aging

Key finding: To date there are few studies examining blood concentrations of neurotrophic factors in large samples of healthy and diseased individuals and no published study specifically addresses peripheral BDNF and NGF levels in late life. +3 more findings

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Restriction in complex activities of daily living in MCI: impact on outcome

62/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Inclusion of instrumental activities of daily living restriction in the criteria of mild cognitive impairment improves the prediction of dementia and the stability of this status over time. +2 more findings

• Early Stage

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Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI

54/100 ✓ Peer-reviewed Mild cognitive impairment Neurology

Key finding: Mild cognitive impairment as originally and currently defined is usually early stage Alzheimer disease, which can begin with a cognitive deficit other than memory.

• Early Stage
• Brain Biology

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Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study

67/100 ✓ Peer-reviewed How common it is The Lancet. Neurology

Key finding: High concentrations of Abeta(1-40) but not Abeta(1-42) at baseline were associated with an increased risk of dementia. +4 more findings

• Risk Factors
• Biomarkers

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Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia

60/100 ✓ Peer-reviewed Disparities Annals of neurology

Key finding: We hypothesized that telomere length might thus relate to increased risk for dementia and mortality. +1 more finding

• Genetics

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Handgrip strength and cognitive decline in older Mexican Americans

53/100 ✓ Peer-reviewed Disparities The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: By contrast, participants in the highest handgrip strength quartile maintained a higher level of cognitive function. +1 more finding

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Limited literacy and mortality in the elderly: the health, aging, and body composition study

53/100 ✓ Peer-reviewed Disparities Journal of general internal medicine

Key finding: Limited literacy is independently associated with a nearly 2-fold increase in mortality in the elderly. +4 more findings

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Predictors of complicated grief among dementia caregivers: a prospective study of bereavement

48/100 ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: This study identifies predictors of complicated grief for which interventions could be developed to not only ease caregiver distress, but also serve as preventive interventions for bereavement.

• Caregiving

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The contribution of voxel-based morphometry in staging patients with mild cognitive impairment

54/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Different patterns of gray matter density distribution in patients with mild cognitive impairment may be associated to different rates of conversion to Alzheimer disease. +2 more findings

• Early Stage

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[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease

66/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Longitudinal studies will be required to determine the association of elevated [(11)C]PIB binding and risk of developing dementia of the Alzheimer type. +1 more finding

• Brain Scans

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Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders

46/100 ✓ Peer-reviewed Getting a diagnosis Journal of Alzheimer's disease : JAD

Key finding: We have employed a multiplex quantitative proteomics method, iTRAQ (isobaric Tagging for Relative and Absolute protein Quantification), in conjunction with multidimensional chromatography, followed by tandem mass spectrometry (MS/MS), to simultaneously measure relative changes in the proteome of cerebrospinal fluid (CSF) obtained from patients with AD, PD, and DLB compared to healthy controls. +2 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Telomere length predicts poststroke mortality, dementia, and cognitive decline

45/100 ✓ Peer-reviewed Prevention and risk Annals of neurology

Key finding: Telomere length is a prognostic marker for poststroke cognitive decline, dementia, and death.

• Prevention
• Diagnosis

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Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial

73/100 ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: These results support the safety and efficacy of memantine for the treatment of mild to moderate AD. +4 more findings

• Treatments
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Brain nicotinic acetylcholine receptors: native subtypes and their relevance

36/100 ✓ Peer-reviewed Risk factors Trends in pharmacological sciences

Key finding: Neuronal nicotinic acetylcholine receptors comprise a heterogeneous class of cationic channels that is present throughout the nervous system. +4 more findings

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Dementia as a predictor of mortality in dialysis patients

52/100 ✓ Peer-reviewed End-of-life care Clinical journal of the American Society of Nephrology : CJASN

Key finding: The average time to death for patients with dementia was 1.09 versus 2.7 yr (P < 0.001) with an adjusted hazard ratio of 1.87 (95% confidence interval 1.77 to 1.98). +1 more finding

Full summary, score breakdown and related studies → Original source

beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons

36/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry

Key finding: Although little is known about the early functional or ultrastructural changes associated with AD, it has been proposed that a stage of synaptic dysfunction might precede neurodegeneration in the development of this disease. +4 more findings

• Brain Biology

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Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease

53/100 ✓ Peer-reviewed Mild cognitive impairment Neurobiology of aging

Key finding: The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. +2 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source