Newest studies

Subjective memory complaint in relation to cognitive performance and depression: a longitudinal study of a rural Chinese population

46/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: SMC was associated with poorer objective memory performance even after controlling the effect of depression and demographic data, but SMC did not predict faster cognitive decline or dementia over 3 years. +4 more findings

• Health Equity

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Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project

56/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Incidence rates of all dementias and of AD increased with age; men and those with lesser education had higher rates of possible/incipient dementia (CDR = 0.5) in this community. +4 more findings

• Health Equity
• Diagnosis
• Risk Factors

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Frequency and clinical determinants of dementia after ischemic stroke

60/100 ✓ Peer-reviewed Disparities Neurology

Key finding: Dementia is frequent after ischemic stroke, occurring in one-fourth of the elderly patients in the authors' cohort. +2 more findings

• Health Equity

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The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and alzheimer disease

44/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Functional MRI has recently been used to examine activation associated with aging and dementia, yet little is known regarding the effect of cerebral atrophy on fMRI signal. +4 more findings

• Brain Scans

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Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects

53/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Registration of serial MRI volume images provides a powerful method of quantification of brain atrophy that can be used to monitor progression of AD in clinical trials.

• Brain Scans
• Treatments
• Clinical Trials

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Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies

50/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: The Consensus criteria for DLB performed as well in this prospective study as those for AD and VaD, with a diagnostic sensitivity substantially higher than that reported by previous retrospective studies. +2 more findings

• Diagnosis
• Other Dementias

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Executive dysfunction and long-term outcomes of geriatric depression

51/100 ✓ Peer-reviewed Getting a diagnosis Archives of general psychiatry

Key finding: Executive dysfunction was found to be associated with relapse and recurrence of geriatric major depression and with residual depressive symptoms. +2 more findings

• Diagnosis

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The role of cerebral ischemia in Alzheimer's disease

57/100 ✓ Peer-reviewed Prevention and risk Neurobiology of aging

Key finding: Recent advances suggest that vascular risk factors linked to cerebrovascular disease and stroke in the elderly significantly increase the risk of developing Alzheimer's disease (AD). +1 more finding

• Risk Factors

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Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity

43/100 ✓ Peer-reviewed Genetics American journal of human genetics

Key finding: In a recent genomic screen of 54 families with late-onset AD, we detected significant evidence for a second late-onset AD locus located on chromosome 12 between D12S373 and D12S390. +4 more findings

• Genetics

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Head injury and the risk of AD in the MIRAGE study

61/100 ✓ Peer-reviewed Genetics Neurology

Key finding: Comparison of probands with their unaffected spouses yielded odds ratios for AD of 9.9 (95% CI, 6.5 to 15.1) for head injury with loss of consciousness and 3.1 (2.3 to 4.0) for head injury without loss of consciousness. +2 more findings

• Genetics
• Risk Factors

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

52/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences

Apolipoprotein E (apoE) alleles determine the age-adjusted relative risk (epsilon4 > epsilon3) for Alzheimer's disease (AD).

• Genetics
• Brain Biology

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Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and 40 concentrations in Alzheimer's disease

45/100 ✓ Peer-reviewed Tau biomarkers Neuroscience letters

Key finding: There was a significant decrease of Abeta42 (P<0.05) and Abeta40 (P<0.05) levels with time. +2 more findings

• Biomarkers
• Brain Biology

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Memory and MRI-based hippocampal volumes in aging and AD

55/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: The volume of the hippocampal formation predicted performance on most acquisition and recall measures across the spectrum of normal aging and AD. +2 more findings

• Brain Scans

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Quality of life in dementia patients in long-term care

59/100 ✓ Peer-reviewed Health systems and care delivery International journal of geriatric psychiatry

Key finding: Residents exhibited better QOL than expected. +3 more findings

• Care Services

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A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study

77/100 ✓ Peer-reviewed Clinical trials Neurology

Key finding: A low-dose regimen of prednisone is not useful in the treatment of AD. +2 more findings

• Clinical Trials
• Treatments

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Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine

40/100 ✓ Peer-reviewed Treatments Annals of neurology

Key finding: Human immunodeficiency virus type 1 (HIV-1) proteins Tat and gp120 have been implicated in the pathogenesis of dementia associated with HIV infection.

• Treatments

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

36/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America

Key finding: Expression of APP and memapsin 2 in HeLa cells showed that memapsin 2 cleaved the beta-secretase site of APP intracellularly. +2 more findings

• Brain Biology

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beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

36/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Using human brain tissues and cells that overexpress either alpha7nAChR or amyloid precursor protein as the starting material, Abeta(1-42) and alpha7nAChR can be co-immunoprecipitated by the respective specific antibodies, suggesting that they are tightly associated.

• Brain Biology

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Oxidative stress and Alzheimer disease

36/100 ✓ Peer-reviewed Genetics The American journal of clinical nutrition

Key finding: Furthermore, lesions are present in the brains of AD patients that are typically associated with attacks by free radicals (eg, damage to DNA, protein oxidation, lipid peroxidation, and advanced glycosylation end products), and metals (eg, iron, copper, zinc, and aluminum) are present that have catalytic activity that produce free radicals. beta-Amyloid is aggregated and produces more free radicals in the presence of free radicals; beta-amyloid toxicity is eliminated by free radical scavengers. +1 more finding

• Brain Biology

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Endogenous estrogen levels and Alzheimer's disease among postmenopausal women

60/100 ✓ Peer-reviewed Vascular contributions Neurology

Key finding: The results of this preliminary case-control study suggest that estradiol levels may decline significantly in women in whom AD develops. +4 more findings

• Genetics

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Delusions and hallucinations in Alzheimer's disease: prevalence and clinical correlates

50/100 ✓ Peer-reviewed Clinical safety International journal of geriatric psychiatry

Key finding: This study confirms the high prevalence of psychotic symptoms in AD patients encountered in clinical practice and suggests that individual psychotic symptoms have different associations. +4 more findings

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Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach

41/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical and experimental neuropsychology

Key finding: Some learning is possible in DAT and a number of factors have been identified which may facilitate performance, although applications to everyday memory problems have been limited. +3 more findings

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Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease

40/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology

Key finding: Long-term cognitive decline in postmenopausal women is associated with aging and Alzheimer disease (AD). +3 more findings

• Genetics

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Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases

55/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology

Key finding: Although four scans showed brainstem pathology, all of these patients had apparently unrelated neurodegenerative diseases known to be associated with RBD. +2 more findings

• Lifestyle

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Memory impairment on free and cued selective reminding predicts dementia

57/100 ✓ Peer-reviewed Getting a diagnosis Neurology

Key finding: Poor performance on free recall from FCSR predicts future dementia. +2 more findings

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