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Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
Storandt M, Grant EA, Miller JP, Morris JC.. Neurology, 2006-08-01
Topic: Risk, prevention and care in population studies
Objectives To compare the natural history of individuals classified with mild cognitive impairment (MCI) in accordance with original criteria to the natural history of individuals classified with revised MCI criteria. Methods The authors compared the rates of progression in 32 individuals with amnestic MCI and in 90 people with MCI according to revised criteria that allow nonamnestic deficits with progression in 276 individuals who were too minimally impaired (pre-MCI) to meet either MCI criteria. All individuals in this study were determined clinically to be very mildly cognitively impaired with a Clinical Dementia Rating (CDR) of 0.5. Results Rates of progression for the two MCI groups were similar with a decline of almost 0.50 SD per year on a psychometric composite. Decline was less (0.23 SD) in the pre-MCI group. Median survival time to CDR 1 (mild dementia) was comparable for the original (95% CI: 3.79 to 4.07 years) and revised (95% CI: 3.29 to 5.40) criteria MCI groups but approximately twice as long in the pre-MCI group (95% CI: 6.72 to 8.93). All cases from the amnestic MCI criteria group with neuropathologic diagnoses met criteria for Alzheimer disease as did more than 90% in the other two groups. Conclusions Mild cognitive impairment as originally and currently defined is usually early stage Alzheimer disease, which can begin with a cognitive deficit other than memory. It is possible to identify Alzheimer disease at an even earlier stage than mild cognitive impairment by focusing on intraindividual change rather than comparison with group norms.
Key findings
- Results Rates of progression for the two MCI groups were similar with a decline of almost 0.50 SD per year on a psychometric composite.
Why it matters
Among very mildly impaired adults (CDR 0.5), people meeting the original memory-only definition of mild cognitive impairment and those meeting the broader revised definition declined at about the same rate (almost 0.50 SD a year on a test composite) and reached mild dementia on similar timescales (median 95% CIs of 3.79–4.07 and 3.29–5.40 years), while a "pre-MCI" group declined about half as fast (0.23 SD a year; 6.72–8.93 years). Among those who came to autopsy, all amnestic-MCI cases and more than 90% of the other two groups met criteria for Alzheimer disease, which led the authors to conclude that MCI under either definition "is usually early stage Alzheimer disease" and that it can begin with problems other than memory. This was an observational follow-up, so it describes typical group courses, not what will happen to any one person.
Study details
- Participants32
- Evidence strengthLow
How this study scored 54/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 1 / 4 | 32 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 284 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.9 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 4 / 6 | Cited 13.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 45 other studies in this library |
| Still being cited | 1 / 4 | Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author John C. Morris: h-index 209 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16894109) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Storandt, M., Grant, E. A., Miller, J. P., & Morris, J. C. (2006). Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI. Neurology. https://doi.org/10.1212/01.wnl.0000228231.26111.6e
Vancouver
Storandt M, Grant EA, Miller JP, Morris JC. Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI. Neurology. 2006. doi:10.1212/01.wnl.0000228231.26111.6e. PMID: 16894109.
BibTeX
@article{storandt2006-16894109,
author = {Storandt, M. and Grant, E. A. and Miller, J. P. and Morris, J. C.},
title = {{Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI}},
journal = {Neurology},
year = {2006},
doi = {10.1212/01.wnl.0000228231.26111.6e},
pmid = {16894109},
url = {https://doi.org/10.1212/01.wnl.0000228231.26111.6e}
}
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