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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,276–24,300 of 27,380 studies, newest first · page 972 of 1096.

January 2004 16

  1. 2004-01-01

    Risk of dementia and alcohol and wine consumption: a review of recent results

    ✓ Peer-reviewed Long-term cohort studies Biological research

    Key finding: Dementia may result from a wide variety of disorders, including degenerative (e.g. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-01-01

    Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications

    ✓ Peer-reviewed Risk genes beyond APOE Advances in experimental medicine and biology

    Key finding: Etiologically, two different types or even diseases exist: inheritance in 5% to 10% of all Alzheimer cases versus 90% to 95% AD cases whith sporadic origin (SAD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-01-01

    Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

    ✓ Peer-reviewed Risk genes beyond APOE Neuroscience

    Key finding: Isolation stress induced by individually housing each mouse from the time of weaning further decreased hippocampal cell proliferation in Tg2576 mice as well as in non-transgenic littermates at 6 months of age. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-01-01

    Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults

    ✓ Peer-reviewed Mild cognitive impairment The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Lesions in the hippocampus (HC), the entorhinal cortex (EC), and the prefrontal cortex (PFC) are associated with impairment of episodic memory; reduced HC volume is linked to memory declines in dementia; and decline in EC volume predicts progression from mild cognitive impairment to dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-01-01

    Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience

    Key finding: Neurodegeneration in fetal development of Down syndrome (DS) patients is proposed to result in apparent neuropathological abnormalities and to contribute to the phenotypic characteristics of mental retardation and premature development of Alzheimer disease.

    Full summary, score breakdown and related studies → Original source

  6. 2004-01-01

    Imaging cerebral atrophy: normal ageing to Alzheimer's disease

    ✓ Peer-reviewed How common it is Lancet (London, England)

    Key finding: Alzheimer's disease is associated with progressive cerebral atrophy, which can be seen on MRI with high resolution. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2004-01-01

    Do caregiver management strategies influence patient behaviour in dementia?

    ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

    Key finding: Caregiver management strategies would appear to be associated with behavioural problems in dementia, and are important in predicting patient behaviour and caregiver burden. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2004-01-01

    Activities of daily living in patients with dementia: clinical relevance, methods of assessment and effects of treatment

    ✓ Peer-reviewed Caregiving CNS drugs

    Key finding: Disability, characterised by the loss of ability to perform activities of daily living (ADL), is a defining feature of dementia that results in growing caregiver burden and the eventual need for alternative care or nursing home placement. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-01-01

    The relationship between neuropsychological functioning and driving ability in dementia: a meta-analysis

    ✓ Peer-reviewed Caregiving Neuropsychology

    Key finding: When studies using a control group were included, the relationship between cognitive measures and on-road or non-road driving measures was significant for all reported domains; mean correlations ranged from.35 to.65. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2004-01-01

    Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study

    ✓ Peer-reviewed Caregiving Neurology

    Key finding: The failure of selective cyclo-oxygenase-2 inhibition to slow the progression of AD may indicate either that the disease process is too advanced to modify in patients with established dementia or that cyclo-oxygenase-2 does not play a significant role in the pathogenesis of the disorder. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-01-01

    Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study

    ✓ Peer-reviewed Getting a diagnosis Archives of general psychiatry

    Key finding: The p-tau proteins in CSF come closest to fulfilling the criteria of a biological marker of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2004-01-01

    DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging

    ✓ Peer-reviewed Getting a diagnosis Neurology

    Key finding: Based on informant report, disturbed arousal and disorganized speech are specific aspects of fluctuations in dementia with Lewy bodies that reliably distinguish dementia with Lewy bodies from Alzheimer's disease and normal aging. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2004-01-01

    Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials

    ✓ Peer-reviewed Getting a diagnosis Archives of neurology

    Key finding: Patients with MCI had a predominant memory impairment with relative sparing of other cognitive domains and were intermediate between clinically normal individuals and patients with AD on cognitive and functional ratings. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2004-01-01

    Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms

    ✓ Peer-reviewed Prevention and risk AIDS (London, England)

    Key finding: Given the general increase in neurological disorders with age and the relatively high prevalence of cognitive dysfunction associated with HIV itself, the risk of HIV-associated dementia (HAD) in this aging HIV-seropositive subgroup is of particular concern. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2004-01-01

    Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study

    ✓ Peer-reviewed Prevention and risk Archives of neurology

    Key finding: Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2004-01-01

    Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

    ✓ Peer-reviewed Treatments JAMA

    Key finding: These results, together with previous studies, suggest that memantine represents a new approach for the treatment of patients with moderate to severe AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

December 2003 9

  1. 2003-12-29

    State of the art of the neurotrophin hypothesis in psychiatric disorders: implications and limitations

    ✓ Peer-reviewed Brain scans and imaging Journal of neural transmission (Vienna, Austria : 1996)

    Key finding: This hypothesis is mainly based on new experimental evidence showing that psychiatric disorders are associated with neuronal atrophy and cell loss, impairments of structural plasticity and cellular resilience due to neurodevelopmental disturbances and morphological abnormalities of the brain. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2003-12-19

    Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

    ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America

    Key finding: We previously found that cognitively normal, late-middle-aged carriers of the apolipoprotein E epsilon4 allele, a common susceptibility gene for late-onset Alzheimer's dementia, have abnormally low rates of glucose metabolism in the same brain regions as patients with probable AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2003-12-16

    The signaling adapter protein DAP12 regulates multinucleation during osteoclast development

    ✓ Peer-reviewed TREM2 and immune genetics Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    Key finding: These data show a new role for DAP12 signaling in regulating formation of multinucleated osteoclasts. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2003-12-03

    Cannabinoid CB2Receptors and Fatty Acid Amide Hydrolase Are Selectively Overexpressed in Neuritic Plaque-Associated Glia in Alzheimer's Disease Brains

    ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroscience

    Key finding: Our results show that both fatty acid amide hydrolase and cannabinoid CB2 receptors are abundantly and selectively expressed in neuritic plaque-associated astrocytes and microglia, respectively, whereas the expression of CB1 receptors remains unchanged. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2003-12-01

    Proneness to psychological distress is associated with risk of Alzheimer's disease

    ✓ Peer-reviewed Long-term cohort studies Neurology

    Key finding: Proneness to experience psychological distress is a risk factor for AD, an effect independent of AD pathologic markers such as cortical plaques and tangles. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2003-12-01

    The built environment and mental health

    ✓ Peer-reviewed Disparities Journal of urban health : bulletin of the New York Academy of Medicine

    Key finding: Insufficient daylight is reliably associated with increased depressive symptoms.

    Full summary, score breakdown and related studies → Original source

  7. 2003-12-01

    Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging

    Key finding: To better mimic this neuropathology, we generated a novel triple transgenic model of AD (3xTg-AD) harboring three mutant genes: beta-amyloid precursor protein (betaAPPSwe), presenilin-1 (PS1M146V), and tauP301L. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2003-12-01

    Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder

    ✓ Peer-reviewed Hippocampus size on brain scans Archives of general psychiatry

    Key finding: These results suggest that BD is associated with decreased volumes of medial temporal lobe structures, with greater effect sizes in the amygdala than in the hippocampus. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2003-12-01

    The aging hippocampus: cognitive, biochemical and structural findings

    ✓ Peer-reviewed Hippocampus size on brain scans Cerebral cortex (New York, N.Y. : 1991)

    Key finding: Aging is often accompanied by learning and memory problems, many of which resemble deficits associated with hippocampal damage. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →