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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal (1)H MRS metabolite changes in patients with MCI, and AD, and to compare (1)H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in (1)H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that (1)H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Kantarci, K., Weigand, S. D., Petersen, R. C., Boeve, B. F., Knopman, D. S., Gunter, J., et al. (2007). Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2006.06.018

Vancouver

Kantarci K, Weigand SD, Petersen RC, Boeve BF, Knopman DS, Gunter J, et al. Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging. 2007. doi:10.1016/j.neurobiolaging.2006.06.018. PMID: 16860440.

BibTeX

@article{kantarci2007-16860440,
  author  = {Kantarci, K. and Weigand, S. D. and Petersen, R. C. and Boeve, B. F. and Knopman, D. S. and Gunter, J. and Reyes, D. and Shiung, M. and others},
  title   = {{Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2007},
  doi     = {10.1016/j.neurobiolaging.2006.06.018},
  pmid    = {16860440},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.06.018}
}

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Key findings

The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly.
The change in (1)H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that (1)H MRS metabolite ratios may be useful markers for the progression of AD.
Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

Why it matters

In this longitudinal study, the N-acetylaspartate/creatine ratio declined in people with mild cognitive impairment and Alzheimer's disease compared to cognitively normal elderly, and changes in these metabolite ratios tracked clinical progression about as well as ventricular expansion. This suggests these ratios may be useful markers for tracking how Alzheimer's disease progresses, though the study does not show they can treat or prevent it.

Study details

Study designlongitudinal study
Evidence strengthModerate

How this study scored 53/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurobiology of aging)
Journal's citation record	3 / 4	Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2007 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 213 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.1 citations a year over 21 year(s) since 2007
Impact for its field and year	3 / 6	Cited 6.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 5 other studies in this library
Still being cited	1 / 4	Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Clifford R. Jack: h-index 203 (OpenAlex, whole career)
Institution's track record	2 / 3	Mayo Clinic: institution h-index 1,606 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 16860440)
Free to read	0 / 2	Behind a paywall — scores zero
Total	53 / 100	—

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