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39/100

✓ Peer-reviewed alzhub usefulness score 39 out of 100. Prevention trials

Topic: Brain proteins, microglia and lab models

Higher MIND diet scores during the follow-up were associated with fewer reactive microglia (i.e., less neuroinflammation) in the hippocampus when controlled for age at death, sex, education, calories, and AD pathology (β=-0.035, SE=0.02, p = 0.045), but not with total microglia (β=-4.88, SE=3.08, p = 0.114). Among calorie-adjusted antioxidant nutrients (models controlled for age at death, sex, education), oleic acid (mono-unsaturated fatty acid) was negatively associated with activated hippocampal microglia (Q5 vs. Q1: β=-0.18, SE=0.08, p = 0.03) and vitamin E, which approached but did not reach significance (Q5 vs. Q1:β=-0.13, SE=0.07, p = 0.08). The MIND diet is associated with microglial inflammation in the hippocampus. Further studies are needed to investigate if the diet's role in lowering the overall neuroinflammatory response explains the association of diet and cognitive health in older persons. Antioxidant nutrient analysis indicates a potential inverse relation between dietary vitamin E and oleic acid with hippocampal microglia that warrants further investigation with bigger sample size.

Key findings

Higher MIND diet scores during the follow-up were associated with fewer reactive microglia (i.e., less neuroinflammation) in the hippocampus when controlled for age at death, sex, education, calories, and AD pathology (β=-0.035, SE=0.02, p = 0.045), but not with total microglia (β=-4.88, SE=3.08, p = 0.114).
Among calorie-adjusted antioxidant nutrients (models controlled for age at death, sex, education), oleic acid (mono-unsaturated fatty acid) was negatively associated with activated hippocampal microglia (Q5 vs.
Q1: β=-0.18, SE=0.08, p = 0.03) and vitamin E, which approached but did not reach significance (Q5 vs.
The MIND diet is associated with microglial inflammation in the hippocampus.
Further studies are needed to investigate if the diet's role in lowering the overall neuroinflammatory response explains the association of diet and cognitive health in older persons.

Why it matters

In this community-based neuropathologic study, higher MIND diet scores were linked to fewer reactive microglia in the hippocampus, suggesting less neuroinflammation. The authors state that further studies are needed to see if this lower inflammatory response explains the diet's link to cognitive health in older persons.

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Study details

Participants237
Evidence strengthLow

How this study scored 39/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	237 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 1 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.3 citations a year over 3 year(s) since 2025
Impact for its field and year	1 / 6	Cited 0.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Julie A. Schneider: h-index 151 (OpenAlex, whole career)
Institution's track record	0 / 3	Rush University Medical Center: institution h-index 670 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41434452)
Free to read	2 / 2	Free to read
Total	39 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Agarwal, P., Kapasi, A., Agrawal, S., Wagner, M., Grodstein, F., Bennett, D. A. A., et al. (2025). The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study. Alzheimer s & Dementia. https://doi.org/10.1002/alz70860_100482

Vancouver

Agarwal P, Kapasi A, Agrawal S, Wagner M, Grodstein F, Bennett DAA, et al. The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study. Alzheimer s & Dementia. 2025. doi:10.1002/alz70860_100482. PMID: 41434452.

BibTeX

@article{agarwal2025-41434452,
  author  = {Agarwal, Puja and Kapasi, Alifiya and Agrawal, Sonal and Wagner, Maude and Grodstein, Francine and Bennett, David A. A. and Barnes, Lisa Laverne and Leurgans, Sue E. and others},
  title   = {{The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_100482},
  pmid    = {41434452},
  url     = {https://doi.org/10.1002/alz70860_100482}
}

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