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40/100

✓ Peer-reviewed alzhub usefulness score 40 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

Sample characteristics are shown in Table 1. The first four principal components (PCs) explained 38% of the variance in the MIND diet-associated metabolites. Figure 1 presents the top seven metabolites for each PC. Regression models (Table 2) identified significant positive PC-biomarker associations: PC1 with ptau217 and NfL; PC2 with GFAP and NfL; PC3 with all four biomarkers; and PC4 with ptau217. Mediation analysis will examine whether these PCs mediate the relationship between the MIND diet and plasma biomarkers. MIND diet-associated plasma metabolite groups correlate with plasma biomarkers of AD and neurodegeneration. These groups of metabolites include essential amino acids, omega-3 fatty acids, plant and gut microbe-derived metabolites, and sphingolipids. These findings highlight the potential importance of dietary interventions in modulating metabolic pathways linked to dementia biomarkers.

Key findings

Sample characteristics are shown in Table 1.
The first four principal components (PCs) explained 38% of the variance in the MIND diet-associated metabolites.
Figure 1 presents the top seven metabolites for each PC.
Regression models (Table 2) identified significant positive PC-biomarker associations: PC1 with ptau217 and NfL; PC2 with GFAP and NfL; PC3 with all four biomarkers; and PC4 with ptau217.
Mediation analysis will examine whether these PCs mediate the relationship between the MIND diet and plasma biomarkers.

Why it matters

This study found that groups of MIND diet-associated plasma metabolites correlate with plasma biomarkers of Alzheimer's disease and neurodegeneration, including ptau217, NfL, and GFAP. It states that mediation analysis will examine whether these metabolites mediate the relationship between the MIND diet and plasma biomarkers, so these findings highlight potential metabolic pathways rather than a proven prevention or treatment.

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Study details

Participants1,104
Evidence strengthModerate

How this study scored 40/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	1,104 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Corinne D. Engelman: h-index 40 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Wisconsin–Madison: institution h-index 1,518 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41434081)
Free to read	2 / 2	Free to read
Total	40 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Denier‐Fields, D. N., Dong, R., Rocha, B. L., Chin, N. A., Reyes, R. E. R., Wilson, R. E., et al. (2025). Diet‐Driven Metabolite Patterns Link the MIND Diet to Dementia Biomarkers. Alzheimer s & Dementia. https://doi.org/10.1002/alz70860_106699

Vancouver

Denier‐Fields DN, Dong R, Rocha BL, Chin NA, Reyes RER, Wilson RE, et al. Diet‐Driven Metabolite Patterns Link the MIND Diet to Dementia Biomarkers. Alzheimer s & Dementia. 2025. doi:10.1002/alz70860_106699. PMID: 41434081.

BibTeX

@article{denierfields2025-41434081,
  author  = {Denier‐Fields, Diandra N. and Dong, Ruocheng and Rocha, Briana L and Chin, Nathaniel A. and Reyes, Ramiro Eduardo Rea and Wilson, Rachael E. and Jonaitis, Erin McMullen and Langhough, Rebecca E. and others},
  title   = {{Diet‐Driven Metabolite Patterns Link the MIND Diet to Dementia Biomarkers}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_106699},
  pmid    = {41434081},
  url     = {https://doi.org/10.1002/alz70860_106699}
}

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