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30/100

✓ Peer-reviewed alzhub usefulness score 30 out of 100. Disease mechanisms

Topic: Brain proteins, microglia and lab models

hONE-NPCs expressed proteins such as Ki67, Nestin, GFAP, and b-III Tubulin, which are associated with cellular proliferation and the neuronal progenitor lineage. The functional characterization of hONE-NPCs in AD and PSP patients revealed duplication times of approximately 90 hours. In the conditioned media, a differential expression of trophic factors released by hONE-NPCs from AD and PSP patients was observed compared to apparently healthy age-matched controls and young controls. The differential expression of trophic factors released by hONE-NPCs in AD and PSP patients is significant compared to apparently healthy participants. These trophic factors are linked to signaling pathways involved in cellular proliferation and survival. This reduction directly impacts cellular proliferation and survival, as demonstrated by phenotypic characterization, showing decreased Ki67 expression relative to the total number of DAPI-stained cells. To date, no studies have focused on the conditioned media or the changes in trophic factors during tauopathies, such as Alzheimer's disease dementia and PSP, in primary cultures of human olfactory neuroepithelial progenitor cells, opening a new research avenue.

Key findings

hONE-NPCs expressed proteins such as Ki67, Nestin, GFAP, and b-III Tubulin, which are associated with cellular proliferation and the neuronal progenitor lineage.
The functional characterization of hONE-NPCs in AD and PSP patients revealed duplication times of approximately 90 hours.
In the conditioned media, a differential expression of trophic factors released by hONE-NPCs from AD and PSP patients was observed compared to apparently healthy age-matched controls and young controls.
The differential expression of trophic factors released by hONE-NPCs in AD and PSP patients is significant compared to apparently healthy participants.
These trophic factors are linked to signaling pathways involved in cellular proliferation and survival.

Why it matters

Cells taken from the noses of people with Alzheimer's disease and progressive supranuclear palsy released different amounts of trophic factors than cells from healthy controls, and showed decreased proliferation. This is early laboratory research on cells and does not show a treatment or cure.

Study details

Evidence strengthLow

How this study scored 30/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author María del Carmen Cárdenas‐Aguayo: h-index 16 (OpenAlex, whole career)
Institution's track record	0 / 3	Universidad Nacional Autónoma de México: institution h-index 668 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41442068)
Free to read	2 / 2	Free to read
Total	30 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Lora‐Marin, O., Padilla-Mendoza, J.-R., Gómez-Ramírez, D. E., & Cárdenas‐Aguayo, M. d. C. (2025). Differential expression of conditioned medium from tauopathies patients' olfactory neuroepithelial precursor cells, implications in the neurodegeneration. Alzheimer s & Dementia. https://doi.org/10.1002/alz70855_104103

Vancouver

Lora‐Marin O, Padilla-Mendoza J.-R, Gómez-Ramírez DE, Cárdenas‐Aguayo MdC. Differential expression of conditioned medium from tauopathies patients' olfactory neuroepithelial precursor cells, implications in the neurodegeneration. Alzheimer s & Dementia. 2025. doi:10.1002/alz70855_104103. PMID: 41442068.

BibTeX

@article{loramarin2025-41442068,
  author  = {Lora‐Marin, Obed‐Ricardo and Padilla-Mendoza, Juan-Ramón and Gómez-Ramírez, Daniela E. and Cárdenas‐Aguayo, María del Carmen},
  title   = {{Differential expression of conditioned medium from tauopathies patients' olfactory neuroepithelial precursor cells, implications in the neurodegeneration}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_104103},
  pmid    = {41442068},
  url     = {https://doi.org/10.1002/alz70855_104103}
}

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