Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
Williams MM, Xiong C, Morris JC, Galvin JE.. Neurology, 2006-12-01
Topic: Amyloid, tau and blood-test diagnosis
Objective To determine whether dementia with Lewy bodies (DLB) progresses more rapidly than Alzheimer disease (AD). Methods We compared 315 participants (63 with DLB and 252 with AD) enrolled in a prospective longitudinal study of memory and aging with annual clinical and cognitive assessments and followed until death. The main outcome measure was dementia progression to institutionalization and death. Neuropathologic examinations were performed on all participants in this study. Subject classification (DLB vs AD) was based on neuropathology. Results Patients with DLB had an increased risk of mortality vs patients with AD (hazard ratio [HR] 1.88, 95% CI: 1.4 to 2.5). The median survival time for DLB was 78.0 years and for AD was 84.6 years (chi(2) = 19.9, p Conclusions Dementia with Lewy bodies (DLB) increases the risk of mortality compared with Alzheimer disease (AD), but the two groups did not differ in rate of cognitive decline. The greater risk for noncognitive disease progression for DLB compared with AD suggests clinically meaningful differences for the two disorders.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Williams, M. M., Xiong, C., Morris, J. C., & Galvin, J. E. (2006). Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology. https://doi.org/10.1212/01.wnl.0000247041.63081.98
Vancouver
Williams MM, Xiong C, Morris JC, Galvin JE. Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology. 2006. doi:10.1212/01.wnl.0000247041.63081.98. PMID: 17159097.
BibTeX
@article{williams2006-17159097,
author = {Williams, M. M. and Xiong, C. and Morris, J. C. and Galvin, J. E.},
title = {{Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease}},
journal = {Neurology},
year = {2006},
doi = {10.1212/01.wnl.0000247041.63081.98},
pmid = {17159097},
url = {https://doi.org/10.1212/01.wnl.0000247041.63081.98}
}
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Key findings
- Results Patients with DLB had an increased risk of mortality vs patients with AD (hazard ratio [HR] 1.88, 95% CI: 1.4 to 2.5).
- The median survival time for DLB was 78.0 years and for AD was 84.6 years (chi(2) = 19.9, p Conclusions Dementia with Lewy bodies (DLB) increases the risk of mortality compared with Alzheimer disease (AD), but the two groups did not differ in rate of cognitive decline.
- The greater risk for noncognitive disease progression for DLB compared with AD suggests clinically meaningful differences for the two disorders.
Why it matters
People with dementia with Lewy bodies had a higher risk of death than people with Alzheimer's disease, but the two groups declined in thinking at similar rates. This is information about disease course and prognosis, not about treating, curing or preventing Alzheimer's disease.
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Study details
- Study designlongitudinal study
- Participants315
- Evidence strengthModerate
How this study scored 62/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 2 / 4 | 315 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 240 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.9 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 3 / 6 | Cited 5.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 18 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author James E. Galvin: h-index 52 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17159097) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 62 / 100 | — |
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