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Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease
Devanand DP, Pradhaban G, Liu X, Khandji A, De Santi S, Segal S, Rusinek H, Pelton GH et al.. Neurology, 2007-03-01
Topic: Amyloid, tau and blood-test diagnosis
Objective To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). Methods Baseline brain MRI was performed in 139 patients with MCI, broadly defined, and 63 healthy controls followed for an average of 5 years (range 1 to 9 years). Results Hippocampal and entorhinal cortex volumes were each largest in controls, intermediate in MCI nonconverters, and smallest in MCI converters to AD (37 of 139 patients converted to AD). In separate Cox proportional hazards models, covarying for intracranial volume, smaller hippocampal volume (risk ratio [RR] 3.62, 95% CI 1.93 to 6.80, p or = 27 out of 30 (21% converted to AD) and in the subset of patients with amnestic MCI (35% converted to AD). In the total patient sample, when both hippocampal and entorhinal volume were entered into an age-stratified Cox model with sex, MMSE, education, and intracranial volume, smaller hippocampal volume (RR 2.21, 95% CI 1.14 to 4.29, p Conclusions Smaller hippocampal and entorhinal cortex volumes each contribute to the prediction of conversion to Alzheimer disease. Age and cognitive variables also contribute to prediction, and the added value of hippocampal and entorhinal cortex volumes is small. Nonetheless, combining these MRI volumes with age and cognitive measures leads to high levels of predictive accuracy that may have potential clinical application.
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APA 7th
Devanand, D. P., Pradhaban, G., Liu, X., Khandji, A., De Santi, S., Segal, S., et al. (2007). Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology. https://doi.org/10.1212/01.wnl.0000256697.20968.d7
Vancouver
Devanand DP, Pradhaban G, Liu X, Khandji A, De Santi S, Segal S, et al. Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology. 2007. doi:10.1212/01.wnl.0000256697.20968.d7. PMID: 17353470.
BibTeX
@article{devanand2007-17353470,
author = {Devanand, D. P. and Pradhaban, G. and Liu, X. and Khandji, A. and De Santi, S. and Segal, S. and Rusinek, H. and Pelton, G. H. and others},
title = {{Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease}},
journal = {Neurology},
year = {2007},
doi = {10.1212/01.wnl.0000256697.20968.d7},
pmid = {17353470},
url = {https://doi.org/10.1212/01.wnl.0000256697.20968.d7}
}
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Key findings
- Results Hippocampal and entorhinal cortex volumes were each largest in controls, intermediate in MCI nonconverters, and smallest in MCI converters to AD (37 of 139 patients converted to AD).
Why it matters
Smaller hippocampal and entorhinal cortex volumes on MRI each helped predict which people with mild cognitive impairment would later develop Alzheimer disease, but the added value beyond age and cognitive measures was small. Combining these MRI volumes with age and cognitive measures led to high levels of predictive accuracy.
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Study details
- Participants139
- Effect sizeRR 2.21
- Evidence strengthLow
Limitations
This is an observational imaging study rather than a trial, and the ‘broadly defined’ MCI used here may not match the exact diagnostic criteria used in other studies.
How this study scored 64/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 139 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 754 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 35.9 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 5 / 6 | Cited 27.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 54 other studies in this library |
| Still being cited | 3 / 4 | Cited 81 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Mony J. de Leon: h-index 127 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17353470) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 64 / 100 | — |
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