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Frontotemporal lobar degeneration: clinical and pathological relationships
Snowden J, Neary D, Mann D.. Acta neuropathologica, 2007-06-14
Topic: Brain proteins, microglia and lab models
Frontotemporal lobar degeneration (FTLD) encompasses a heterogeneous group of clinical syndromes that include frontotemporal dementia (FTD), frontotemporal dementia with motor neurone disease (FTD/MND), progressive non-fluent aphasia (PNFA), semantic dementia (SD) and progressive apraxia (PAX). Clinical phenotype is often assumed to be a poor predictor of underlying histopathology. Advances in immunohistochemistry provide the opportunity to re-examine this assumption.
Key findings
- Clinical phenotype is often assumed to be a poor predictor of underlying histopathology.
- Advances in immunohistochemistry provide the opportunity to re-examine this assumption.
- We classified pathological material from 79 FTLD brains, blind to clinical diagnosis, according to topography of brain atrophy and immunohistochemical characteristics.
- There were highly significant relationships to clinical syndrome.
Why it matters
This study classified brain tissue from 79 people with frontotemporal lobar degeneration and found significant relationships between clinical syndrome and pathology. It is a pathological study and does not test any treatment or cure.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 300 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.3 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 4 / 6 | Cited 15.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 27 other studies in this library |
| Still being cited | 2 / 4 | Cited 18 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author David Mann: h-index 99 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Manchester: institution h-index 1,304 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17569065) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Snowden, J., Neary, D., & Mann, D. (2007). Frontotemporal lobar degeneration: clinical and pathological relationships. Acta neuropathologica. https://doi.org/10.1007/s00401-007-0236-3
Vancouver
Snowden J, Neary D, Mann D. Frontotemporal lobar degeneration: clinical and pathological relationships. Acta neuropathologica. 2007. doi:10.1007/s00401-007-0236-3. PMID: 17569065.
BibTeX
@article{snowden2007-17569065,
author = {Snowden, J. and Neary, D. and Mann, D.},
title = {{Frontotemporal lobar degeneration: clinical and pathological relationships}},
journal = {Acta neuropathologica},
year = {2007},
doi = {10.1007/s00401-007-0236-3},
pmid = {17569065},
url = {https://doi.org/10.1007/s00401-007-0236-3}
}
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