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Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
Keith A. Johnson, Matt Gregas, John Alex Becker, Catherine Kinnecom, David H. Salat, Erin K. Moran, Eric Edward Smith, Jonathan M. Rosand, Dorene M. Rentz, William E. Klunk, Chester A. Mathis, Julie C. Price, Steven T. DeKosky, Alan J. Fischman, Steven Mark Greenberg. Annals of Neurology, 2007-08-07
Topic: Amyloid, tau and blood-test diagnosis
OBJECTIVE: Cerebrovascular deposition of beta-amyloid (cerebral amyloid angiopathy [CAA]) is a major cause of hemorrhagic stroke and a likely contributor to vascular cognitive impairment. We evaluated positron emission tomographic imaging with the beta-amyloid-binding compound Pittsburgh Compound B (PiB) as a potential noninvasive method for detection of CAA. We hypothesized that amyloid deposition would be observed with PiB in CAA, and based on the occipital predilection of CAA pathology and associated hemorrhages, that specific PiB retention would be disproportionately greater in occipital lobes. METHODS: We compared specific cortical PiB retention in 6 nondemented subjects diagnosed with probable CAA with 15 healthy control subjects and 9 patients with probable Alzheimer's disease (AD). RESULTS: All CAA and AD subjects were PiB-positive, both by distribution volume ratio measurements and by visual inspection of positron emission tomographic images. Global cortical PiB retention was significantly increased in CAA (distribution volume ratio 1.18 +/- 0.06) relative to healthy control subjects (1.04 +/- 0.10; p = 0.0009), but was lower in CAA than in AD subjects (1.41 +/- 0.17; p = 0.002). The occipital-to-global PiB ratio, however, was significantly greater in CAA than in AD subjects (0.99 +/- 0.07 vs 0.86 +/- 0.05; p = 0.003). INTERPRETATION: We conclude that PiB-positron emission tomography can detect cerebrovascular beta-amyloid and may serve as a method for identifying the extent of CAA in living subjects.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Johnson, K. A., Gregas, M., Becker, J. A., Kinnecom, C., Salat, D. H., Moran, E. K., et al. (2007). Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Annals of Neurology. https://doi.org/10.1002/ana.21164
Vancouver
Johnson KA, Gregas M, Becker JA, Kinnecom C, Salat DH, Moran EK, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Annals of Neurology. 2007. doi:10.1002/ana.21164. PMID: 17683091.
BibTeX
@article{johnson2007-17683091,
author = {Johnson, Keith A. and Gregas, Matt and Becker, John Alex and Kinnecom, Catherine and Salat, David H. and Moran, Erin K. and Smith, Eric Edward and Rosand, Jonathan M. and Rentz, Dorene M. and Klunk, William E. and Mathis, Chester A. and Price, Julie C. and DeKosky, Steven T. and Fischman, Alan J. and Greenberg, Steven Mark},
title = {{Imaging of amyloid burden and distribution in cerebral amyloid angiopathy}},
journal = {Annals of Neurology},
year = {2007},
doi = {10.1002/ana.21164},
pmid = {17683091},
url = {https://doi.org/10.1002/ana.21164}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 15 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
PiB PET scans detected amyloid in all 6 people with probable cerebral amyloid angiopathy (amyloid deposits in brain blood vessels) and all 9 with probable Alzheimer's. Overall retention was lower in angiopathy than in Alzheimer's but relatively greater in the occipital lobes, and the authors conclude the scan may help gauge angiopathy in living people.
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How this study scored 53/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 50 of the 95 points we could judge it on, which is 53 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of Neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 498 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 23.7 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 4 / 6 | Cited 17.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 27 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Steven Mark Greenberg: h-index 144 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17683091) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 50 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 50 of the 95 points we could judge it on is 53 out of 100. |
| Total | 53 / 100 | — |
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