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Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease
Apostolova LG, Steiner CA, Akopyan GG, Dutton RA, Hayashi KM, Toga AW, Cummings JL, Thompson PM.. Archives of neurology, 2007-10-01
Topic: Amyloid, tau and blood-test diagnosis
Background Alzheimer disease (AD) is the most common form of dementia worldwide. Mild cognitive impairment (MCI) is the recent terminology for patients with cognitive deficiencies in the absence of functional decline. Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to dementia at a rate of 10% to 15% per year.
Key findings
- Mild cognitive impairment (MCI) is the recent terminology for patients with cognitive deficiencies in the absence of functional decline.
- Most patients with MCI harbor the pathologic changes of AD and demonstrate transition to dementia at a rate of 10% to 15% per year.
- Patients with AD and MCI experience progressive brain atrophy.
- Objective To analyze the structural magnetic resonance imaging data for 24 patients with amnestic MCI and 25 patients with mild AD using an advanced 3-dimensional cortical mapping technique.
Why it matters
This cross-sectional study used 3-dimensional mapping of MRI data from 24 patients with amnestic mild cognitive impairment and 25 with mild Alzheimer's disease to look at gray matter atrophy. It describes brain changes in the disease, not a treatment or cure.
Study details
- Study designcross-sectional
- Participants24
- Evidence strengthModerate
How this study scored 55/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | 3 / 4 | Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 24 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 152 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.2 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 3 / 6 | Cited 6.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paul M. Thompson: h-index 193 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, Los Angeles: institution h-index 1,923 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17923632) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 55 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/archneur.64.10.1489
- PubMed: 17923632
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Apostolova, L. G., Steiner, C. A., Akopyan, G. G., Dutton, R. A., Hayashi, K. M., Toga, A. W., et al. (2007). Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease. Archives of neurology. https://doi.org/10.1001/archneur.64.10.1489
Vancouver
Apostolova LG, Steiner CA, Akopyan GG, Dutton RA, Hayashi KM, Toga AW, et al. Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease. Archives of neurology. 2007. doi:10.1001/archneur.64.10.1489. PMID: 17923632.
BibTeX
@article{apostolova2007-17923632,
author = {Apostolova, L. G. and Steiner, C. A. and Akopyan, G. G. and Dutton, R. A. and Hayashi, K. M. and Toga, A. W. and Cummings, J. L. and Thompson, P. M.},
title = {{Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease}},
journal = {Archives of neurology},
year = {2007},
doi = {10.1001/archneur.64.10.1489},
pmid = {17923632},
url = {https://doi.org/10.1001/archneur.64.10.1489}
}
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