Newest studies

Increased matrix metalloproteinase 9 activity in mild cognitive impairment

43/100 ✓ Peer-reviewed Mild cognitive impairment Journal of neuropathology and experimental neurology

Key finding: The analysis demonstrated greater MMP-9 activity in both AD and mild cognitive impairment compared with no cognitive impairment brain samples (p < 0.01), which supports the notion that a metabolic failure in the NGF-maturation/degradation pathway may be associated with an exacerbated degradation of mNGF in the cerebral cortex in early AD. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

51/100 ✓ Peer-reviewed Lewy body dementia The Journal of cell biology

Key finding: Under basal conditions, loss of VCP activity results in autophagosome accumulation. +1 more finding

Full summary, score breakdown and related studies → Original source

Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Archives of neurology

Key finding: Transactive response DNA-binding protein 43 pathology occurs in FAD and DS, similar to that observed in sporadic Alzheimer disease. +1 more finding

• Down Syndrome
• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report

50/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Clinical, cognitive, and CSF markers consistent with AD may precede detection of cerebral amyloid beta using amyloid imaging agents such as PiB that primarily label fibrillar amyloid beta plaques. +1 more finding

• Biomarkers
• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging

58/100 ✓ Peer-reviewed Brain scans and imaging JAMA

Key finding: Circulating leptin was associated with a reduced incidence of dementia and AD and with cerebral brain volume in asymptomatic older adults. +3 more findings

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease

60/100 ✓ Peer-reviewed Brain scans and imaging Archives of neurology

Key finding: Preclinical AD as detected by PET PiB is not benign, as it is associated with progression to symptomatic AD. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

80/100 ✓ Peer-reviewed Treatments JAMA

Key finding: Tarenflurbil did not slow cognitive decline or the loss of activities of daily living in patients with mild AD. +2 more findings

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial

79/100 ✓ Peer-reviewed Genetics JAMA

Key finding: Compared with placebo, the use of G. biloba, 120 mg twice daily, did not result in less cognitive decline in older adults with normal cognition or with mild cognitive impairment. +2 more findings

• Clinical Trials
• Genetics

Full summary, score breakdown and related studies → Original source

Adenosine A2AReceptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by β-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

40/100 ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

Key finding: Together, these results show that A(2A)Rs play a crucial role in the development of Abeta-induced synaptotoxicity leading to memory dysfunction through a p38 MAPK (mitogen-activated protein kinase)-dependent pathway and provide a molecular basis for the benefits of caffeine consumption in AD.

• Brain Biology
• Prevention

Full summary, score breakdown and related studies → Original source

Prediction of pathology in primary progressive language and speech disorders

54/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: The different anatomic distribution of the pathologic lesions could explain these results: opercular and subcortical regions in tau pathologies with progressive anarthria, the left frontotemporal cortex in TDP-43-positive frontotemporal lobar degeneration (FTLD-TDP) with agrammatic progressive aphasia, the bilateral lateral and anterior temporal cortex in FTLD-TDP or argyrophilic grain disease with semantic dementia, and the left parietotemporal cortex in Alzheimer disease with logopenic progressive aphasia or jargon aphasia. +1 more finding

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services

62/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: These findings suggest a potential vasculoprotective role of vitamin D. +1 more finding

Full summary, score breakdown and related studies → Original source

Alzheimer's disease: synaptic dysfunction and Abeta

40/100 ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration

Key finding: Synapse loss is an early and invariant feature of Alzheimer's disease (AD) and there is a strong correlation between the extent of synapse loss and the severity of dementia. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Prediction of institutionalization in the elderly. A systematic review

65/100 ✓ Peer-reviewed Risk factors Age and ageing

Key finding: This study provides a systematic review of predictors of NHP in the general population of developed countries. +2 more findings

Full summary, score breakdown and related studies → Original source

How predictive is the MMSE for cognitive performance after stroke?

49/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology

Key finding: Neuropsychological testing is time-consuming and not easy to administer after hospital discharge. +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Hypertension and dementia

39/100 ✓ Peer-reviewed Prevention and risk American journal of hypertension

Key finding: Recent studies have shown that disruption of diurnal blood pressure (BP) variation is closely associated with cognitive impairment via injury of the small cerebral arteries indicating that long-standing hypertension constitutes a risk of brain matter atrophy or white matter lesions (WMLs).

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

59/100 ✓ Peer-reviewed Lewy body dementia Acta Neuropathologica

• Other Dementias

Full summary, score breakdown and related studies → Original source

Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio

43/100 ✓ Peer-reviewed Tau biomarkers PloS one

Key finding: Presenilin 1(PS1) is the catalytic subunit of gamma-secretase, the enzyme responsible for the Abeta C-terminal cleavage site, which results in the production of Abeta peptides of various lengths. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

74/100 ✓ Peer-reviewed Treatments Neurology

Key finding: No significant differences were found in the primary efficacy analysis. +1 more finding

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Changing perspectives regarding late-life dementia

46/100 ✓ Peer-reviewed Brain tissue and pathology Nature reviews. Neurology

Key finding: Development of effective preventive and treatment strategies for late-life dementia relies on a deep understanding of all the processes involved. +3 more findings

Full summary, score breakdown and related studies → Original source

CSF phospho-tau is independent of age, cognitive status and gender of neurological patients

33/100 ✓ Peer-reviewed Tau biomarkers Journal of neurology

Key finding: Unlike total-tau (t-tau), age related changes of this promising biomarker are sparsely studied. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

69/100 ✓ Peer-reviewed Treatments Neurobiology of aging

Key finding: The plasma Aβ40/Aβ42 ratio increased in the control group, but showed no significant change in the pioglitazone group. +1 more finding

Full summary, score breakdown and related studies → Original source

Does neuroinflammation fan the flame in neurodegenerative diseases?

40/100 ✓ Peer-reviewed Inflammation and the immune system Molecular Neurodegeneration

Key finding: Neurodegenerative CNS disorders, including multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), tauopathies, and age-related macular degeneration (ARMD), are associated with chronic neuroinflammation and elevated levels of several cytokines.

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease

40/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: Recent imaging evidence in Alzheimer's disease suggests that neural involvement in early-stage disease is more complex than is encapsulated in the commonly held position of predominant mesial temporal lobe degeneration-there is also early posterior cingulate cortex and diencephalic damage. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease

48/100 ✓ Peer-reviewed Mild cognitive impairment Neuroscience letters

Key finding: Some studies have demonstrated an accumulation of products of free radical damage in the central nervous system and in the peripheral tissues of subjects with AD or mild cognitive impairment. +3 more findings

• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Epidemiological studies of the effect of stroke on incident dementia: a systematic review

64/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: The effect of stroke on dementia incidence in the population is not explained by common risk factors. +3 more findings

• Risk Factors
• Genetics

Full summary, score breakdown and related studies → Original source