Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,901–24,925 of 27,380 studies, newest first · page 997 of 1096.
April 2002 1
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2002-04-01
Association between apolipoprotein E genotype and Alzheimer disease in African American subjects
58/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Compared with individuals with the APOEepsilon3/epsilon3, the odds of having AD were significantly increased among those with 1 or more copies of the epsilon4 allele; the odds ratio (OR) for the epsilon3/epsilon4 genotype was 2.6 (95% confidence interval [CI], 1.8-3.7), and the OR for the epsilon4/epsilon4 genotype was 10.5 (95% CI, 5.1-21.8). +2 more findings
Full summary, score breakdown and related studies → Original source
March 2002 24
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2002-03-18
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
40/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of cell biology
Key finding: The data suggests a linkage between tau and APP trafficking, which may be significant in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2002-03-05
A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping
44/100 ✓ Peer-reviewed Cognitive tests and assessment European journal of nuclear medicine and molecular imaging
Key finding: Forty-eight AD, 23 DLB and 20 age-matched control subjects participated. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Comparison of Citalopram, Perphenazine, and Placebo for the Acute Treatment of Psychosis and Behavioral Disturbances in Hospitalized, Demented Patients
36/100 ✓ Peer-reviewed Clinical safety American Journal of Psychiatry
Key finding: Patients treated with citalopram or perphenazine showed statistically significant improvement on several Neurobehavioral Rating Scale factor scores. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-03 month only
Apolipoprotein E affects amyloid formation but not amyloid growth in vitro: mechanistic implications for apoE4 enhanced amyloid burden and risk for Alzheimer's disease
38/100 ✓ Peer-reviewed Genetics Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
Key finding: Consistent with the altered pathology and enhanced risk for AD associated with inheritance of the epsilon4 allele, we conclude that APOE epsilon4 is a risk factor for AD not due to a pathological gain of function of apoE4 but to a loss of protective function of apoE3.
Full summary, score breakdown and related studies → Original source
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2002-03-01
Clinical predictive factors of subthalamic stimulation in Parkinson's disease
40/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: The selection criteria were severe parkinsonian motor disability, clear response of symptoms to levodopa, occurrence of disabling levodopa-related motor complications and the absence of dementia and significant abnormalities on brain MRI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-03-01
Prevalence and impact of medical comorbidity in Alzheimer's disease
43/100 ✓ Peer-reviewed Health systems and care delivery The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Despite the limitation of a cross-sectional design, our initial findings suggest that there is a strong association between medical comorbidity and cognitive status in AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Serum lipoprotein levels, statin use, and cognitive function in older women
43/100 ✓ Peer-reviewed Drug development Archives of neurology
Key finding: High LDL and total cholesterol levels are associated with cognitive impairment, and lowering these lipoprotein levels may be a strategy for preventing impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Glycogen synthase kinase 3: an emerging therapeutic target
36/100 ✓ Peer-reviewed Drug development Trends in molecular medicine
Key finding: GSK-3 inhibitors might prove useful as therapeutic compounds in the treatment of conditions associated with elevated levels of enzyme activity, such as type 2 diabetes and Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2002-03-01
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine
36/100 ✓ Peer-reviewed Treatments Biochemistry
Key finding: It revealed that the carbamyl moiety is covalently linked to the active-site serine, with the leaving group, (-)-S-3-[1-(dimethylamino)ethyl]phenol, being retained in the "anionic" site. +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-03-01
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells
36/100 ✓ Peer-reviewed Drug development The Journal of pharmacology and experimental therapeutics
Key finding: We observed that GLP-1 and exendin-4 induced neurite outgrowth in a manner similar to nerve growth factor (NGF), which was reversed by coincubation with the selective GLP-1 receptor antagonist exendin (9-39). +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-03-01
Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review
36/100 ✓ Peer-reviewed Genetics American journal of epidemiology
Key finding: Allelic variation in apo var epsilon is consistently associated with plasma concentrations of total cholesterol, LDL cholesterol, and apo B (the major protein of LDL, VLDL, and chylomicrons). +1 more finding
Full summary, score breakdown and related studies → Original source
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2002-03-01
End-of-life care in dementia: a review of problems, prospects, and solutions in practice
36/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: The purpose of this literature review was to assess the current state of affairs in end-of-life care for persons with dementia, to identify barriers to the provision of high-quality care, and to describe exemplary programs that have discovered ways to overcome these barriers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
The prevalence and documentation of impaired mental status in elderly emergency department patients
45/100 ✓ Peer-reviewed Clinical safety Annals of emergency medicine
Key finding: Study objective We sought to determine the prevalence of mental status impairment in elderly emergency department patients and to assess documentation of and referrals by emergency physicians for mental status impairment after discharge from the ED.
Full summary, score breakdown and related studies → Original source
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2002-03-01
What is cognitive reserve? Theory and research application of the reserve concept
55/100 ✓ Peer-reviewed Disease mechanisms Journal of the International Neuropsychological Society
The idea of reserve against brain damage stems from the repeated observation that there does not appear to be a direct relationship between the degree of brain pathology or brain damage and the clinical manifestation of that damage.
Full summary, score breakdown and related studies → Original source
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2002-03-01
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice
48/100 ✓ Peer-reviewed Inflammation and the immune system The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: This reduction was associated with a dramatic increase in the number of microglia expressing major histocompatibility complex-II antigen, a marker for microglial activation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease
45/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neural transmission (Vienna, Austria : 1996)
Key finding: AD changes are frequently present in brains of demented PD patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Provisional diagnostic criteria for depression of Alzheimer disease
43/100 ✓ Peer-reviewed Brain tissue and pathology The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
The authors, a group of investigators with extensive research and clinical experience related to both late-life depression and Alzheimer disease (AD), propose provisional affective and behavioral inclusion and exclusion diagnostic criteria for Depression of AD.
Full summary, score breakdown and related studies → Original source
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2002-03-01
Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease
50/100 ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry
Key finding: The short and long term effects of CEIs were evaluated in 135 patients with probable Alzheimer's disease relative to 135 patients who were never exposed to CEIs matched by age, education, duration of the symptoms, and cognitive status. +3 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Functional deficits in patients with mild cognitive impairment: prediction of AD
50/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: These findings indicate that in patients with MCI, the patient's lack of awareness of functional deficits identified by informants strongly predicts a future diagnosis of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Cytonectin expression in Alzheimer disease
27/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neuropathology and experimental neurology
Key finding: The protein is overexpressed in Alzheimer disease entorhinal cortex as compared to normal age-matched controls.
Full summary, score breakdown and related studies → Original source
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2002-03-01
Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study
61/100 ✓ Peer-reviewed Risk factors Annals of neurology
Key finding: Silent brain infarcts and white matter lesions are frequently seen on magnetic resonance imaging in healthy elderly people and both are associated with an increased risk of stroke and dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2002-03-01
Revealing a hidden problem. An evaluation of a community dementia case-finding program from the Indian 10/66 dementia research network
40/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry
Key finding: This simple cost-effective case-finding method can be of practical use in the development of community based dementia care services in India and other developing countries with similar health care systems.
Full summary, score breakdown and related studies → Original source
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2002-03-01
Sensitivity and specificity of cognitive and functional screening instruments for dementia: the Indo-U.S. Dementia Epidemiology Study
49/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: The sensitivity of the HMSE alone was nonsignificantly improved by the addition of either the EASI or the neuropsychological battery, whereas its specificity was significantly decreased by either addition.
Full summary, score breakdown and related studies → Original source
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2002-03-01
A descriptive evaluation of eligibility for therapy among veterans with chronic hepatitis C virus infection
43/100 ✓ Peer-reviewed Disparities Journal of clinical gastroenterology
Key finding: Goal To assess the number of chronic hepatitis C patients eligible for therapy. +1 more finding
Full summary, score breakdown and related studies → Original source
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