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The relationship between cerebrospinal fluid biomarkers and depression in elderly women
Gudmundsson P, Skoog I, Waern M, Blennow K, Pálsson S, Rosengren L, Gustafson D.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2007-10-01
Topic: Risk, prevention and care in population studies
Objective Cerebrospinal fluid (CSF) biomarkers including the 42 amino-acid form of beta-amyloid (Abeta42), total tau protein (T-tau), and the CSF/serum albumin ratio are markers of brain pathology and metabolism. Abeta42 and T-tau are sometimes used to discriminate geriatric depression from mild forms of Alzheimer disease (AD) in clinical studies. However, studies focusing on the relationship between these CSF biomarkers and geriatric depression are lacking.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gudmundsson, P., Skoog, I., Waern, M., Blennow, K., Pálsson, S., Rosengren, L., et al. (2007). The relationship between cerebrospinal fluid biomarkers and depression in elderly women. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1097/jgp.0b013e3180547091
Vancouver
Gudmundsson P, Skoog I, Waern M, Blennow K, Pálsson S, Rosengren L, et al. The relationship between cerebrospinal fluid biomarkers and depression in elderly women. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2007. doi:10.1097/jgp.0b013e3180547091. PMID: 17911361.
BibTeX
@article{gudmundsson2007-17911361,
author = {Gudmundsson, P. and Skoog, I. and Waern, M. and Blennow, K. and Pálsson, S. and Rosengren, L. and Gustafson, D.},
title = {{The relationship between cerebrospinal fluid biomarkers and depression in elderly women}},
journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
year = {2007},
doi = {10.1097/jgp.0b013e3180547091},
pmid = {17911361},
url = {https://doi.org/10.1097/jgp.0b013e3180547091}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Abeta42 and T-tau are sometimes used to discriminate geriatric depression from mild forms of Alzheimer disease (AD) in clinical studies.
- However, studies focusing on the relationship between these CSF biomarkers and geriatric depression are lacking.
- Methods This was a cross-sectional study with a population-based sample of 84 nondemented elderly women in Sweden.
- Measurements included neuropsychiatric, physical, and lumbar puncture examinations, with Diagnostic and Statistical Manual of Mental Disorders, Third Revision-based depression diagnoses and measurement of CSF levels of Abeta42, T-tau, albumin, and serum albumin.
Why it matters
This cross-sectional study of 84 nondemented elderly women examined whether CSF biomarkers Abeta42 and T-tau relate to depression, noting that studies on this relationship are lacking. It does not test any treatment, prevention, or cure for Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designcross-sectional
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry) |
| Journal's citation record | 2 / 4 | American Journal of Geriatric Psychiatry: journal h-index 178 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 114 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.4 citations a year over 21 year(s) since 2007 |
| Impact for its field and year | 2 / 6 | Cited 1.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Deborah Gustafson: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Gothenburg: institution h-index 972 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17911361) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
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