Newest studies

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

68/100 ✓ Peer-reviewed Cognitive tests and assessment The Lancet. Neurology

Key finding: The amyloid-beta peptide Abeta(42) has been implicated in the pathogenesis of Alzheimer's disease (AD). +3 more findings

• Clinical Trials
• Diagnosis

Full summary, score breakdown and related studies → Original source

A mathematical model of glutathione metabolism

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Theoretical biology & medical modelling

Key finding: We show that the glutathione pools in hepatic cells and in the blood are quite insensitive to fluctuations in amino acid input and offer an explanation based on model predictions.

Full summary, score breakdown and related studies → Original source

Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients

53/100 ✓ Peer-reviewed Brain scans and imaging Stroke

Key finding: The risk of vascular or mixed dementia, but not of other types of dementia, was significantly increased in MCI patients with a large amount of subcortical hyperintensities at baseline. +4 more findings

• Early Stage
• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase

48/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

Key finding: Although oxidative stress has been implicated in the AD pathogenesis by inducing Abeta production, the underlying mechanism remains elusive. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Health service utilization among Alzheimer's disease patients: evidence from managed care

57/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Few studies have examined the disease burden of AD in commercial managed care settings. +2 more findings

Full summary, score breakdown and related studies → Original source

Functional recovery after hip fracture: the combined effects of depressive symptoms, cognitive impairment, and delirium

57/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

Key finding: Cognitive and mood disorders were common in elderly hip fracture patients and were associated with greater risk of poor outcomes, both independently and in combination. +3 more findings

Full summary, score breakdown and related studies → Original source

Fatty acids and oxidative stress in psychiatric disorders

40/100 ✓ Peer-reviewed Clinical safety BMC psychiatry

Key finding: Most psychiatric disorders are associated with increased oxidative stress. +1 more finding

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Family caregivers' strains: comparative analysis of cancer caregiving with dementia, diabetes, and frail elderly caregiving

64/100 ✓ Peer-reviewed Caregiving Journal of aging and health

Key finding: The comparative analysis provided a systematic review of cancer caregiving in the context of three other types of caregiving.

• Caregiving
• Risk Factors

Full summary, score breakdown and related studies → Original source

Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways

36/100 ✓ Peer-reviewed Brain scans and imaging Progress in neurobiology

Key finding: These effects comprise changes in intracellular cyclic nucleotides (cAMP, cGMP) and calcium levels, activation of certain protein kinase C subtypes, intracellular localization of steroid hormone receptors and regulation of G protein signaling proteins. +4 more findings

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APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway

53/100 ✓ Peer-reviewed Brain tissue and pathology BMC neurology

Key finding: The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. +3 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder

43/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuroradiology

Key finding: The automated hippocampal volumetric methods showed good agreement with manual hippocampal volumetry, but the volume measured using FreeSurfer was 35% larger and the agreement was questionable with IBASPM. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

40/100 ✓ Peer-reviewed Genetics Journal of Alzheimer s Disease

Key finding: In contrast, memory-impaired epsilon4+ subjects demonstrated a relative decline in verbal memory. +1 more finding

• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

Effectiveness of nonpharmacological interventions in delaying the institutionalization of patients with dementia: a meta-analysis

79/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

Key finding: A systematic review with a meta-analysis was therefore conducted to estimate the overall effectiveness of nonpharmacological support programs for caregivers and patients with dementia that are intended to delay institutionalization. +3 more findings

• Policy

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Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease

40/100 ✓ Peer-reviewed TREM2 and immune genetics Neurochemical research

Key finding: Loss of a functional Trem2 signaling pathway is the genetic cause of Nasu-Hakola disease. +3 more findings

• Genetics

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Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease

50/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Emotion recognition progresses from a deficit in low-intensity fearful facial recognition in a-MCI phase to a deficit in all intensities and emotions in mild AD. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

47/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: Inflammation is associated with Abeta pathology in Alzheimer's disease (AD) and transgenic AD models. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study

58/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Plasma A beta levels are affected by age and by systemic and CNS vascular risk factors. +3 more findings

• Risk Factors
• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype

50/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: The presence of abnormal TDP-43 immunoreactivity is associated with a modified Alzheimer disease clinicopathologic and radiologic phenotype. +4 more findings

• Brain Scans
• Brain Biology

Full summary, score breakdown and related studies → Original source

Impaired insulin secretion increases the risk of Alzheimer disease

61/100 ✓ Peer-reviewed Genetics Neurology

Key finding: In this longitudinal study, impaired acute insulin response at midlife was associated with an increased risk of Alzheimer disease (AD) up to 35 years later suggesting a causal link between insulin metabolism and the pathogenesis of AD. +3 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease

60/100 ✓ Peer-reviewed Genetics Neurology

Key finding: APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease. +2 more findings

• Genetics

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Dementia and effort test performance

41/100 ✓ Peer-reviewed Cognitive tests and assessment The Clinical neuropsychologist

Key finding: We examined archival data from 214 non-litigating patients with dementia on 18 effort indices derived from 12 tests (WAIS-III/WAIS-R Digit Span and Vocabulary, Dot Counting Test, Warrington Recognition Memory Test-Words, WMS-III Logical Memory, Rey Word Recognition Memory Test, Finger Tapping, b-Test, Rey 15-Item, Test of Memory Malingering, Rey Auditory Verbal Learning Test, and Rey Complex Figure Test). +2 more findings

Full summary, score breakdown and related studies → Original source

The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12

41/100 ✓ Peer-reviewed TREM2 and immune genetics Infection and immunity

Key finding: ROS production depends on the NADPH oxidase, but little is known about the innate immune receptors and proximal adapters that regulate Salmonella-induced ROS. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

49/100 ✓ Peer-reviewed Risk genes beyond APOE Brain research

Key finding: Here, we find that EGCG administered orally in drinking water (50 mg/kg) similarly reduces Abeta deposition in these mice. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

61/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology

Key finding: We identified two variants in TARDBP, which would encode Gly290Ala and Gly298Ser forms of TDP-43, in two kindreds with familial ALS. +1 more finding

• Genetics
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

58/100 ✓ Peer-reviewed Lewy body dementia Nature medicine

Key finding: These pathological changes suggest that Parkinson's disease is an ongoing process that can affect grafted cells in the striatum in a manner similar to host dopamine neurons in the substantia nigra. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source