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Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study
Reitz C, Bos MJ, Hofman A, Koudstaal PJ, Breteler MM.. Stroke, 2007-11-15
Topic: Risk, prevention and care in population studies
Background and purpose Several studies indicate that stroke increases the risk of dementia. Most of these studies lacked the ability to take accurately assessed prestroke cognitive function into account. Whether the effects of stroke merely unravel an ongoing underlying dementing process or in fact cause the dementia has implications for the prevention of dementia in persons with cerebrovascular disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Reitz, C., Bos, M. J., Hofman, A., Koudstaal, P. J., & Breteler, M. M. (2008). Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study. Stroke. https://doi.org/10.1161/strokeaha.107.490334
Vancouver
Reitz C, Bos MJ, Hofman A, Koudstaal PJ, Breteler MM. Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study. Stroke. 2008. doi:10.1161/strokeaha.107.490334. PMID: 18006863.
BibTeX
@article{reitz2008-18006863,
author = {Reitz, C. and Bos, M. J. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
title = {{Prestroke cognitive performance, incident stroke, and risk of dementia: the Rotterdam Study}},
journal = {Stroke},
year = {2008},
doi = {10.1161/strokeaha.107.490334},
pmid = {18006863},
url = {https://doi.org/10.1161/strokeaha.107.490334}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Most of these studies lacked the ability to take accurately assessed prestroke cognitive function into account.
- Whether the effects of stroke merely unravel an ongoing underlying dementing process or in fact cause the dementia has implications for the prevention of dementia in persons with cerebrovascular disease.
- We explored in a prospective cohort study whether stroke occurrence was related to a higher risk of subsequent dementia and whether this association was dependent on prestroke slope of cognitive function.
- Methods Cox proportional hazard models were used to relate incident stroke as a time-varying exposure with the risk of dementia in 6724 participants of the Rotterdam Study without dementia or stroke at baseline (49,361 person years of follow-up).
Why it matters
This study explored whether stroke was related to a higher risk of subsequent dementia while accounting for prestroke cognitive function. It does not show that preventing stroke prevents dementia, and the findings are from an observational cohort.
Study details
- Study designcohort study
- Participants6,724
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Stroke) |
| Journal's citation record | 3 / 4 | Stroke: journal h-index 455 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 6,724 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 106 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.3 citations a year over 20 year(s) since 2008 |
| Impact for its field and year | 3 / 6 | Cited 4.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Monique M.B. Breteler: h-index 162 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18006863) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
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