Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,376–19,400 of 27,380 studies, newest first · page 776 of 1096.
July 2012 6
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2012-07-01
Postoperative delirium: a 76-year-old woman with delirium following surgery
57/100 ✓ Peer-reviewed Prevention and risk JAMA
Key finding: Delirium (acute confusion) complicates 15% to 50% of major operations in older adults and is associated with other major postoperative complications, prolonged length of stay, poor functional recovery, institutionalization, dementia, and death.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Rivastigmine treatment for the prevention of electroconvulsive therapy-induced memory deficits in patients with schizophrenia
53/100 ✓ Peer-reviewed Treatments Clinical neuropharmacology
Key finding: However, ECT is associated with cognitive adverse effects, most notably, memory loss. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-07-01
[Chinese herbal medicine for patients with mild to moderate Alzheimer disease based on syndrome differentiation: a randomized controlled trial]
51/100 ✓ Peer-reviewed Treatments Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Key finding: The cognitive functions of the patients in the CMG and WMG were improved after treatment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-07-01
CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial
62/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: The results show that the feasibility, treatment adherence, and carer commitment were excellent. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-07-01
Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures
72/100 ✓ Peer-reviewed Treatments Archives of neurology
Key finding: Antioxidants did not influence CSF biomarkers related to amyloid or tau pathology.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Shapes of the trajectories of 5 major biomarkers of Alzheimer disease
57/100 ✓ Peer-reviewed Genetics Archives of neurology
Key finding: Biomarker trajectory shapes by MMSE score were complex and were affected by interactions with age and APOE status. +2 more findings
Full summary, score breakdown and related studies → Original source
June 2012 19
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2012-06-30
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
36/100 ✓ Peer-reviewed Prevention trials Neurobiology of disease
Key finding: Substantial evidence indicates that physical activity enhances learning and memory for people of all ages, including individuals that suffer from cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-29
Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition
60/100 ✓ Peer-reviewed Risk factors PloS one
Key finding: Survival analyses indicated that subjects with the lowest EF scores were more likely to fall sooner and more likely to experience multiple falls during the 66 months of follow-up (p Conclusions/significance These findings demonstrate that among community-living older adults, the risk of future falls was predicted by performance on EF and attention tests conducted 5 years earlier. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-28
Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes
36/100 ✓ Peer-reviewed Brain scans and imaging Neurotoxicity research
Key finding: The efficacy of melatonin in preventing oxidative damage in either cultured neuronal cells or in the brains of animals treated with various neurotoxic agents, suggests that melatonin has a potential therapeutic value as a neuroprotective drug in treatment of Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), stroke, and brain trauma. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-28
Non-stationarity in the "resting brain's" modular architecture
76/100 ✓ Peer-reviewed Brain scans and imaging PloS one
Key finding: We found that differences in connectivity we and others have previously observed in Alzheimer's disease can be explained by differences in dwell time in DMN sub-network configurations, rather than steady state connectivity magnitude.
Full summary, score breakdown and related studies → Original source
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2012-06-28
Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study
60/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology
Key finding: For one of the primary analyses, the interpretation of the florbetapir scans (majority interpretation of five nuclear medicine physicians, who classified each scan as amyloid positive or amyloid negative) was compared with amyloid pathology (assessed according to the Consortium to Establish a Registry for Alzheimer's Disease standards, and classed as amyloid positive for moderate or frequent plaques or amyloid negative for no or sparse plaques); correlation of the image analysis results with amyloid burden was tested as a coprimary endpoint. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-28
Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation
62/100 ✓ Peer-reviewed Genetics PLoS genetics
Key finding: All samples were male, without significant Alzheimer disease pathology and with extensive pathological annotation available. 507 of the 39,122 analyzed expression probes were different between PD and control samples at false discovery rate (FDR) of 5%. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-27
Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease
40/100 ✓ Peer-reviewed Biomarkers Journal of Anatomy
Key finding: Here, we analysed the astrocytic cytoskeletal changes within the mPFC of a triple transgenic mouse model of AD (3 × Tg-AD) by measuring the surface area and volume of glial fibrillary acidic protein (GFAP)-positive profiles in relation to the build-up and presence of amyloid-β (Aβ), and compared the results with those found in non-transgenic control animals at different ages. 3 × Tg-AD animals showed clear astroglial cytoskeletal atrophy, which appeared at an early age (3 months; 33% and 47% decrease in GFAP-positive surface area and volume, respectively) and remained throughout the disease progression at 9, 12 and 18 months old (29% and 36%; 37% and 35%; 43% and 37%, respectively). +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-06-27
Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study
66/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.
Full summary, score breakdown and related studies → Original source
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2012-06-26
Contribution of individual diseases to death in older adults with multiple diseases
55/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: The use of methods that focus on determining a single underlying cause may lead to underestimation of the extent of the contribution of some diseases such as dementia and respiratory disease to death in older adults and overestimation of the contribution of other diseases.
Full summary, score breakdown and related studies → Original source
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2012-06-26
Advances in understanding the molecular basis of frontotemporal dementia
51/100 ✓ Peer-reviewed Disparities Nature reviews. Neurology
Key finding: Until recently, the underlying cause was known in only a minority of cases that were associated with abnormalities of the tau protein or gene.
Full summary, score breakdown and related studies → Original source
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2012-06-26
Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample
55/100 ✓ Peer-reviewed Brain scans and imaging Brain and behavior
Key finding: MRI hippocampal volumes were significantly lower in bilateral HS compared to AD (p < 0.001) and in unilateral HS cases compared to cases with intact hippocampi (p < 0.001).
Full summary, score breakdown and related studies → Original source
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2012-06-25
Sparse learning and stability selection for predicting MCI to AD conversion using baseline ADNI data
44/100 ✓ Peer-reviewed Long-term cohort studies BMC neurology
Key finding: Patients with Mild Cognitive Impairment (MCI) are at high risk of progression to Alzheimer's dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-25
Micrographia and related deficits in Parkinson's disease: a cross-sectional study
55/100 ✓ Peer-reviewed Digital health tools BMJ open
Key finding: Micrographia was found in nearly half of the PD cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-23
Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment
36/100 ✓ Peer-reviewed Digital health tools Neuropharmacology
Key finding: Significant memory improvement occurred after either intracereboventricular infusion with Compound 44 (100 μg) in a water maze task or systemic administration with Compound 6 (3 mg/kg) in a radial arm maze task.
Full summary, score breakdown and related studies → Original source
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2012-06-22
Atypical antipsychotics are associated with incident diabetes in older adults without schizophrenia or bipolar disorder
36/100 ✓ Peer-reviewed Health systems and care delivery Evidence-Based Mental Health
Key finding: Atypical antipsychotics are associated with incident diabetes in older adults without schizophrenia or bipolar disorder QUESTION Question: Is atypical antipsychotic use associated with incident diabetes or hyperlipidaemia in older people without schizophrenia or bipolar disorder?
Full summary, score breakdown and related studies → Original source
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2012-06-21
A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer's disease: the DARAD trial
64/100 ✓ Peer-reviewed Mild cognitive impairment International journal of geriatric psychiatry
Key finding: Twelve months' treatment with doxycycline or rifampin, alone or in combination, has no beneficial effects on cognition or function in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-20
Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
74/100 ✓ Peer-reviewed Clinical trials Neurology
Key finding: The beneficial effect of DBS on motor function was stable and comparable by target over 36 months. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-20
Novel late-onset Alzheimer disease loci variants associate with brain gene expression
62/100 ✓ Peer-reviewed Genetics Neurology
Key finding: CLU and MS4A4A eSNPs may at least partly explain the LOAD risk association at these loci. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-06-19
Excess costs of dementia disorders and the role of age and gender - an analysis of German health and long-term care insurance claims data
40/100 ✓ Peer-reviewed Digital health tools BMC health services research
Key finding: Dementia poses a substantial additional burden to the German social security system, with the long-term care sector being more seriously challenged than the health care sector. +3 more findings
Full summary, score breakdown and related studies → Original source
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