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Gene expression profile of the bone microenvironment in human fragility fracture bone
Hopwood B, Tsykin A, Findlay DM, Fazzalari NL.. Bone, 2008-09-10
Topic: Brain proteins, microglia and lab models
Osteoporosis (OP) is a common age-related systemic skeletal disease, with a strong genetic component, characterised by loss of bone mass and strength, which leads to increased bone fragility and susceptibility to fracture. Although some progress has been made in identifying genes that may contribute to OP disease, much of the genetic component of OP has yet to be accounted for. Therefore, to investigate the molecular basis for the changes in bone causally involved in OP and fragility fracture, we have used a microarray approach.
Key findings
- Although some progress has been made in identifying genes that may contribute to OP disease, much of the genetic component of OP has yet to be accounted for.
- Therefore, to investigate the molecular basis for the changes in bone causally involved in OP and fragility fracture, we have used a microarray approach.
- We have analysed altered gene expression in human OP fracture bone by comparing mRNA in bone from individuals with fracture of the neck of the proximal femur (OP) with that from age-matched individuals with osteoarthritis (OA), and control (CTL) individuals with no known bone pathology.
- The OA sample set was included because an inverse association, with respect to bone density, has been reported between OA and the OP individuals.
Why it matters
This study used microarrays to compare gene expression in bone from people with hip fragility fractures and age-matched controls, in the context of osteoporosis. It is not about Alzheimer's disease and reports no treatment, cure, or prevention for it.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Bone) |
| Journal's citation record | 3 / 4 | Bone: journal h-index 270 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 114 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.0 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 3 / 6 | Cited 5.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Nicola L. Fazzalari: h-index 42 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The University of Adelaide: institution h-index 918 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 18840552) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Hopwood, B., Tsykin, A., Findlay, D. M., & Fazzalari, N. L. (2009). Gene expression profile of the bone microenvironment in human fragility fracture bone. Bone. https://doi.org/10.1016/j.bone.2008.08.120
Vancouver
Hopwood B, Tsykin A, Findlay DM, Fazzalari NL. Gene expression profile of the bone microenvironment in human fragility fracture bone. Bone. 2009. doi:10.1016/j.bone.2008.08.120. PMID: 18840552.
BibTeX
@article{hopwood2009-18840552,
author = {Hopwood, B. and Tsykin, A. and Findlay, D. M. and Fazzalari, N. L.},
title = {{Gene expression profile of the bone microenvironment in human fragility fracture bone}},
journal = {Bone},
year = {2009},
doi = {10.1016/j.bone.2008.08.120},
pmid = {18840552},
url = {https://doi.org/10.1016/j.bone.2008.08.120}
}
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