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Efficient colonic mucosal wound repair requires Trem2 signaling
Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS.. Proceedings of the National Academy of Sciences of the United States of America, 2008-12-24
Topic: Brain proteins, microglia and lab models
The colonic epithelial lining undergoes constant replacement, driven by epithelial stem cells in crypts of Lieberkühn. Stem cells lost because of damage or disease can be replaced by adjacent crypts that undergo fission. The close proximity of an extraordinary number of luminal microbes creates a challenge for this repair process; infection must be prevented while immune system activation and epithelial stem cell genetic damage must be minimized.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Seno, H., Miyoshi, H., Brown, S. L., Geske, M. J., Colonna, M., & Stappenbeck, T. S. (2009). Efficient colonic mucosal wound repair requires Trem2 signaling. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0803343106
Vancouver
Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS. Efficient colonic mucosal wound repair requires Trem2 signaling. Proceedings of the National Academy of Sciences of the United States of America. 2009. doi:10.1073/pnas.0803343106. PMID: 19109436.
BibTeX
@article{seno2009-19109436,
author = {Seno, H. and Miyoshi, H. and Brown, S. L. and Geske, M. J. and Colonna, M. and Stappenbeck, T. S.},
title = {{Efficient colonic mucosal wound repair requires Trem2 signaling}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2009},
doi = {10.1073/pnas.0803343106},
pmid = {19109436},
url = {https://doi.org/10.1073/pnas.0803343106}
}
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Key findings
- Stem cells lost because of damage or disease can be replaced by adjacent crypts that undergo fission.
- The close proximity of an extraordinary number of luminal microbes creates a challenge for this repair process; infection must be prevented while immune system activation and epithelial stem cell genetic damage must be minimized.
- To understand the factors that modulate crypt/stem cell replacement in the mouse colon, we developed an in vivo acute injury system analogous to punch biopsy of the skin.
- In contrast to epidermal stem cells, colonic epithelial progenitors did not migrate over the wound bed.
Why it matters
This study found that colonic mucosal wound repair in mice requires Trem2 signaling. It concerns the colon, not the brain, and does not address treating, curing or preventing Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Proceedings of the National Academy of Sciences of the United States of America) |
| Journal's citation record | 4 / 4 | Proceedings of the National Academy of Sciences: journal h-index 1,167 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 284 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.9 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 4 / 6 | Cited 8.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 14 other studies in this library |
| Still being cited | 2 / 4 | Cited 45 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Thaddeus S. Stappenbeck: h-index 82 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Washington University in St. Louis: institution h-index 1,962 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19109436) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
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