Home › Research › Risk genes beyond APOE
Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production
Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, Bredesen DE, Mehlen P.. Cell death and differentiation, 2009-01-16
Topic: Brain proteins, microglia and lab models
The beta-amyloid precursor protein (APP) is an orphan transmembrane receptor whose physiological role is largely unknown. APP is cleaved by proteases generating amyloid-beta (Abeta) peptide, the main component of the amyloid plaques that are associated with Alzheimer's disease. Here, we show that APP binds netrin-1, a multifunctional guidance and trophic factor.
Key findings
- APP is cleaved by proteases generating amyloid-beta (Abeta) peptide, the main component of the amyloid plaques that are associated with Alzheimer's disease.
- Here, we show that APP binds netrin-1, a multifunctional guidance and trophic factor.
- Netrin-1 binding modulates APP signaling triggering APP intracellular domain (AICD)-dependent gene transcription.
- Furthermore, netrin-1 binding suppresses Abeta peptide production in brain slices from Alzheimer model transgenic mice.
Why it matters
This study found that netrin-1 binds APP and that this binding suppresses amyloid-beta peptide production in brain slices from Alzheimer model transgenic mice. This is a laboratory and animal study and does not show any treatment, cure, or prevention for Alzheimer's disease in humans.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell death and differentiation) |
| Journal's citation record | 3 / 4 | Cell Death and Differentiation: journal h-index 313 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 123 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.5 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 3 / 6 | Cited 4.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 28 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Patrick Mehlen: h-index 75 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19148186) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/cdd.2008.191
- PubMed: 19148186
- Original source →
- Free full text: Cell Death and Differentiation →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Lourenço, F. C., Galvan, V., Fombonne, J., Corset, V., Llambi, F., Müller, U., et al. (2009). Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell death and differentiation. https://doi.org/10.1038/cdd.2008.191
Vancouver
Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, et al. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell death and differentiation. 2009. doi:10.1038/cdd.2008.191. PMID: 19148186.
BibTeX
@article{lourenco2009-19148186,
author = {Lourenço, F. C. and Galvan, V. and Fombonne, J. and Corset, V. and Llambi, F. and Müller, U. and Bredesen, D. E. and Mehlen, P.},
title = {{Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production}},
journal = {Cell death and differentiation},
year = {2009},
doi = {10.1038/cdd.2008.191},
pmid = {19148186},
url = {https://doi.org/10.1038/cdd.2008.191}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
3 studies in the alzhub library list this one in their references.