Home › Research › Risk genes beyond APOE
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Jean‐Charles Lambert, Simon Charles Heath, Gaël Even, Dominique Campion, Kristel Sleegers, Mikko Hiltunen, Onofre Combarros et al.. Nature Genetics, 2009-09-06
Topic: Amyloid, tau and blood-test diagnosis
The authors conducted a large genome-wide association study using 2,032 individuals from France with Alzheimer's disease and 5,328 controls. Markers outside APOE showing suggestive evidence of association were further examined in collections from Belgium, Finland, Italy, and Spain totaling 3,978 cases and 3,297 controls. The study identified and replicated evidence of association for variants at two loci, CLU on chromosome 8 and CR1 on chromosome 1, with Alzheimer's disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
the European Alzheimer's Disease Initiative Investigators, Lambert, J., Heath, S. C., Even, G., Campion, D., Sleegers, K., et al. (2009). Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nature Genetics. https://doi.org/10.1038/ng.439
Vancouver
the European Alzheimer's Disease Initiative Investigators, Lambert J, Heath SC, Even G, Campion D, Sleegers K, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nature Genetics. 2009. doi:10.1038/ng.439.
BibTeX
@article{study2009-591259cf,
author = {{the European Alzheimer's Disease Initiative Investigators} and Lambert, Jean‐Charles and Heath, Simon Charles and Even, Gaël and Campion, Dominique and Sleegers, Kristel and Hiltunen, Mikko and Combarros, Onofre and others},
title = {{Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease}},
journal = {Nature Genetics},
year = {2009},
doi = {10.1038/ng.439},
url = {https://doi.org/10.1038/ng.439}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Replicated evidence of association was found within CLU (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7.5 x 10(-9) for combined data) on chromosome 8.
- Replicated evidence of association was found within CR1 (rs6656401, OR = 1.21, 95% CI 1.14-1.29, P = 3.7 x 10(-9) for combined data) on chromosome 1.
- Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques.
Why it matters
A genome-wide association study reporting variants at CLU and CR1 associated with Alzheimer's disease. The finding marks genes for further study and is not itself a treatment or a means of prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 64/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Nature Genetics) |
| Journal's citation record | 4 / 4 | Nature Genetics: journal h-index 776 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,233 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 117.5 citations a year over 19 year(s) since 2009 |
| Impact for its field and year | 6 / 6 | Cited 101.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 5 / 6 | Cited by 164 other studies in this library |
| Still being cited | 4 / 4 | Cited 203 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Philippe Amouyel: h-index 140 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 37 institution(s) in 6 countries |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
164 studies in the alzhub library list this one in their references. Showing the 8 highest-scoring.
Related studies in Risk genes beyond APOE
Also tagged “precursor”
1,339 studies in the library carry the topic tag “precursor”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,339 tagged studies.