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56/100

✓ Peer-reviewed alzhub usefulness score 56 out of 100. Brain tissue and pathology

Topic: Amyloid, tau and blood-test diagnosis

Unlabelled An (18)F-labeled PET amyloid-beta (Abeta) imaging agent could facilitate the clinical evaluation of late-life cognitive impairment by providing an objective measure for Alzheimer disease (AD) pathology. Here we present the results of a clinical trial with (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45 or florbetapir [corrected] F 18). Methods An open-label, multicenter brain imaging, metabolism, and safety study of (18)F-AV-45 was performed on 16 patients with AD (Mini-Mental State Examination score, 19.3 +/- 3.1; mean age +/- SD, 75.8 +/- 9.2 y) and 16 cognitively healthy controls (HCs) (Mini-Mental State Examination score, 29.8 +/- 0.45; mean age +/- SD, 72.5 +/- 11.6 y).

Key findings

Here we present the results of a clinical trial with (E)-4-(2-(6-(2-(2-(2-(18)F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine ((18)F-AV-45 or florbetapir [corrected] F 18).
Methods An open-label, multicenter brain imaging, metabolism, and safety study of (18)F-AV-45 was performed on 16 patients with AD (Mini-Mental State Examination score, 19.3 +/- 3.1; mean age +/- SD, 75.8 +/- 9.2 y) and 16 cognitively healthy controls (HCs) (Mini-Mental State Examination score, 29.8 +/- 0.45; mean age +/- SD, 72.5 +/- 11.6 y).
Dynamic PET was performed over a period of approximately 90 min after injection of the tracer (370 MBq [10 mCi]).
Standardized uptake values and cortical-to-cerebellum standardized uptake value ratios (SUVRs) were calculated.

Why it matters

This small open-label study gave the amyloid PET tracer florbetapir (18F-AV-45) to 16 people with Alzheimer's disease and 16 cognitively healthy controls, scanning for about 90 minutes and calculating uptake ratios against the cerebellum. The authors' rationale was that such a tracer "could facilitate the clinical evaluation of late-life cognitive impairment," but the text held here stops at the methods, so it reports no imaging, accuracy or safety results. It is a scan study, not a test of any treatment.

Study details

Study designopen-label trial
Participants16
Evidence strengthLow

How this study scored 56/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	Design recorded as “open-label trial”, which our rubric does not rank (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	1 / 4	16 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 683 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	37.9 citations a year over 18 year(s) since 2010
Impact for its field and year	5 / 6	Cited 36.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	4 / 6	Cited by 51 other studies in this library
Still being cited	3 / 4	Cited 58 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Michael J. Pontecorvo: h-index 56 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 6 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20501908)
Free to read	0 / 2	Behind a paywall — scores zero
Total	56 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

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Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Wong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., et al. (2010). In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.109.069088

Vancouver

Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, et al. In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010. doi:10.2967/jnumed.109.069088. PMID: 20501908.

BibTeX

@article{wong2010-20501908,
  author  = {Wong, D. F. and Rosenberg, P. B. and Zhou, Y. and Kumar, A. and Raymont, V. and Ravert, H. T. and Dannals, R. F. and Nandi, A. and others},
  title   = {{In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2010},
  doi     = {10.2967/jnumed.109.069088},
  pmid    = {20501908},
  url     = {https://doi.org/10.2967/jnumed.109.069088}
}

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