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Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition
Montagne B, Boulin M, Hamel A, Champetier P, Rehel S, Mézenge F, Landeau B, Delarue M et al.. medRxiv, 2025-12-27
Topic: Brain imaging, connectivity and assessment
INTRODUCTION Sleep disturbances are prevalent in patients with Alzheimer’s disease (AD) and may emerge before overt clinical symptoms. We characterized sleep alterations in cognitively unimpaired older adults with cerebral amyloid deposition, and assessed their associations with regional amyloid deposition, cognitive and psychoaffective outcomes. METHODS Seventy-six older adults (69.1 ± 3.4 years, 63.2% female) underwent a multi-night (4.5 ± 0.8 nights) objective sleep assessment using the Somno-Art ® wearable device, Florbetapir-PET scanning, and an extensive neuropsychological and psychoaffective evaluation. RESULTS Amyloid β (Aβ)-positive individuals had a shorter total sleep time (TST) and greater night-to-night variability in rapid eye movement (REM) sleep duration than Aβ-negative individuals. Across the whole sample, these sleep characteristics were associated with increased Aβ deposition in widespread brain regions, but not with cognitive or psychoaffective measures. DISCUSSION Shorter sleep duration and greater REM sleep variability may index early AD-related brain changes, warranting longitudinal studies to establish their prognostic significance. Age-Well randomized clinical trial of the Medit-Ageing European Project. Trial registration number: EudraCT:2016–002,441–36; IDRCB:2016-A01767–44; ClinicalTrials.gov Identifier: NCT02977819
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APA 7th
Montagne, B., Boulin, M., Hamel, A., Champetier, P., Rehel, S., Mézenge, F., et al. (2025). Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition. medRxiv. https://doi.org/10.64898/2025.12.19.25342684
Vancouver
Montagne B, Boulin M, Hamel A, Champetier P, Rehel S, Mézenge F, et al. Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition. medRxiv. 2025. doi:10.64898/2025.12.19.25342684.
BibTeX
@article{montagne2025-7a89a129,
author = {Montagne, B. and Boulin, M. and Hamel, A. and Champetier, P. and Rehel, S. and Mézenge, F. and Landeau, B. and Delarue, M. and others},
title = {{Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition}},
journal = {medRxiv},
year = {2025},
doi = {10.64898/2025.12.19.25342684},
url = {https://doi.org/10.64898/2025.12.19.25342684}
}
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Key findings
- RESULTS Amyloid β (Aβ)-positive individuals had a shorter total sleep time (TST) and greater night-to-night variability in rapid eye movement (REM) sleep duration than Aβ-negative individuals.
- Across the whole sample, these sleep characteristics were associated with increased Aβ deposition in widespread brain regions, but not with cognitive or psychoaffective measures.
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Study details
- Study designlongitudinal study
- Effect size63.2%
- Evidence strengthHigh
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 40 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 62 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (medRxiv) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 25 of the 62 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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