Home › Research › Tau biomarkers
Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status
Kancheva AK, Lyall DM, Tsvetanov KA, Kancheva IK, Mavromati K, Koychev I, Tari B, Garcia DJ et al.. Journal of the American Heart Association, 2025-12-30
Topic: Amyloid, tau and blood-test diagnosis
Background Plasma biomarkers may aid Alzheimer disease (AD) diagnosis and prognosis. Cardiovascular risk contributes to cognitive decline in AD, but whether it modifies the relationship between plasma biomarkers and cognitive status has not been assessed in a large multisite cohort. We aimed to explore if cardiovascular risk moderates plasma AD biomarkers' relationship with cognitive status.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kancheva, A. K., Lyall, D. M., Tsvetanov, K. A., Kancheva, I. K., Mavromati, K., Koychev, I., et al. (2026). Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status. Journal of the American Heart Association. https://doi.org/10.1161/jaha.125.044438
Vancouver
Kancheva AK, Lyall DM, Tsvetanov KA, Kancheva IK, Mavromati K, Koychev I, et al. Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status. Journal of the American Heart Association. 2026. doi:10.1161/jaha.125.044438. PMID: 41467404.
BibTeX
@article{kancheva2026-41467404,
author = {Kancheva, A. K. and Lyall, D. M. and Tsvetanov, K. A. and Kancheva, I. K. and Mavromati, K. and Koychev, I. and Tari, B. and Garcia, D. J. and others},
title = {{Cardiovascular Risk as a Moderator of the Relationship Between Plasma Alzheimer Disease Biomarkers and Cognitive Status}},
journal = {Journal of the American Heart Association},
year = {2026},
doi = {10.1161/jaha.125.044438},
pmid = {41467404},
url = {https://doi.org/10.1161/jaha.125.044438}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Cardiovascular risk contributes to cognitive decline in AD, but whether it modifies the relationship between plasma biomarkers and cognitive status has not been assessed in a large multisite cohort.
- We aimed to explore if cardiovascular risk moderates plasma AD biomarkers' relationship with cognitive status.
- Methods We included cognitively normal (n=301) participants and participants with mild cognitive impairment or probable AD (n=444) from the Bio-Hermes-001 study.
- Cardiovascular risk was quantified using the Atherosclerotic Cardiovascular Disease risk calculator.
Why it matters
This study explored whether cardiovascular risk changes the link between plasma Alzheimer's biomarkers and cognitive status in a large multisite cohort. It is about how biomarkers are interpreted, not about treating, curing or preventing the disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants301
- Effect size56.8%
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Heart Association) |
| Journal's citation record | 2 / 4 | Journal of the American Heart Association: journal h-index 200 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 2 / 4 | 301 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.5 citations a year over 2 year(s) since 2026 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Terence J. Quinn: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 9 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41467404) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1161/jaha.125.044438
- PubMed: 41467404
- Original source →
- Free full text: Journal of the American Heart Association →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 15.
Related studies in Tau biomarkers
Also tagged “cerebrospinal”
821 studies in the library carry the topic tag “cerebrospinal”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 821 tagged studies.