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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Genetics

Topic: Amyloid, tau and blood-test diagnosis

Objective To compare the annual change in MRI and CSF biomarkers in cognitively normal (CN), amnestic mild cognitive impairment (aMCI), and Alzheimer disease (AD). Comparisons were based on intergroup discrimination, correlation with concurrent cognitive/functional changes, relationships to APOE genotype, and sample sizes for clinical trials. Methods We used data from the Alzheimer's Disease Neuroimaging Initiative study consisting of CN, aMCI, and AD cohorts with both baseline and 12-month follow-up CSF and MRI. The annual change in CSF (total-tau [t-tau], Abeta(1-42)) and MRI (change in ventricular volume) was obtained in 312 subjects (92 CN, 149 aMCI, 71 AD). Results There was no significant average annual change in either CSF biomarker in any clinical group except t-tau in CN; moreover, the annual change did not differ by clinical group in pairwise comparisons. In contrast, annual increase in ventricular volume increased in the following order, AD > aMCI > CN, and differences were significant between all clinical groups in pairwise comparisons. Ventricular volume increase correlated with concurrent worsening on cognitive/functional indices in aMCI and AD whereas evidence of a similar correlation with change in CSF measures was unclear. The annual changes in MRI differed by APOE epsilon4 status overall and among aMCI while annual changes in CSF biomarkers did not. Estimated sample sizes for clinical trials are notably less for MRI than the CSF or clinical measures. Conclusions Unlike the CSF biomarkers evaluated, changes in serial structural MRI are correlated with concurrent change on general cognitive and functional indices in impaired subjects, track with clinical disease stage, and are influenced by APOE genotype.

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APA 7th

Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Trojanowski, J. Q., Shaw, L. M., et al. (2010). Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology. https://doi.org/10.1212/wnl.0b013e3181e7ca82

Vancouver

Vemuri P, Wiste HJ, Weigand SD, Knopman DS, Trojanowski JQ, Shaw LM, et al. Serial MRI and CSF biomarkers in normal aging, MCI, and AD. Neurology. 2010. doi:10.1212/wnl.0b013e3181e7ca82. PMID: 20625167.

BibTeX

@article{vemuri2010-20625167,
  author  = {Vemuri, P. and Wiste, H. J. and Weigand, S. D. and Knopman, D. S. and Trojanowski, J. Q. and Shaw, L. M. and Bernstein, M. A. and Aisen, P. S. and others},
  title   = {{Serial MRI and CSF biomarkers in normal aging, MCI, and AD}},
  journal = {Neurology},
  year    = {2010},
  doi     = {10.1212/wnl.0b013e3181e7ca82},
  pmid    = {20625167},
  url     = {https://doi.org/10.1212/wnl.0b013e3181e7ca82}
}

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Key findings

Results There was no significant average annual change in either CSF biomarker in any clinical group except t-tau in CN; moreover, the annual change did not differ by clinical group in pairwise comparisons.
In contrast, annual increase in ventricular volume increased in the following order, AD > aMCI > CN, and differences were significant between all clinical groups in pairwise comparisons.
The annual changes in MRI differed by APOE epsilon4 status overall and among aMCI while annual changes in CSF biomarkers did not.

Why it matters

In this study comparing annual change in MRI and CSF biomarkers across cognitively normal, amnestic mild cognitive impairment, and Alzheimer's disease groups, there was no significant average annual change in either CSF biomarker in any group except total-tau in cognitively normal people. In contrast, annual increase in ventricular volume increased in the order Alzheimer's disease greater than mild cognitive impairment greater than cognitively normal, and it correlated with worsening cognition in the impaired groups.

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Study details

Participants312
Evidence strengthLow

How this study scored 55/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	2 / 4	312 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 155 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.6 citations a year over 18 year(s) since 2010
Impact for its field and year	4 / 6	Cited 15.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 22 other studies in this library
Still being cited	1 / 4	Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Clifford R. Jack: h-index 203 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Pennsylvania: institution h-index 1,859 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20625167)
Free to read	0 / 2	Behind a paywall — scores zero
Total	55 / 100	—

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