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62/100

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

Background The Sydney Memory and Ageing Study (Sydney MAS) was initiated in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time. Methods Non-demented community-dwelling individuals (N = 1037) aged 70-90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 554 individuals, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The cohort is to be followed up with brief telephone reviews annually, and detailed assessments biannually. Results This is a generally well-functioning cohort mostly living in private homes and rating their health as being better than average, although vascular risk factors are common. Most (95.5%) participants or their informants identified a cognitive difficulty, and 43.5% had impairment on at least one neuropsychological test. MCI criteria were met by 34.8%; with 19.3% qualifying for amnestic MCI, whereas 15.5% had non-amnestic MCI; 1.6% had impairment on neuropsychological test performance but no subjective complaints; and 5.8% could not be classified. The rate of MCI was 30.9% in the youngest (70-75) and 39.1% in the oldest (85-90) age bands. Rates of depression and anxiety were 7.1% and 6.9% respectively. Conclusions Cognitive complaints are common in the elderly, and nearly one in three meet criteria for MCI. Longitudinal follow-up of this cohort will delineate the progression of complaints and objective cognitive impairment, and the determinants of such change.

Key findings

Results This is a generally well-functioning cohort mostly living in private homes and rating their health as being better than average, although vascular risk factors are common.

Why it matters

Among 1037 Sydney residents aged 70-90 without dementia, 95.5% (or someone who knew them) reported a memory or thinking difficulty, but 43.5% showed impairment on a test, and 34.8% met criteria for mild cognitive impairment, 30.9% at ages 70-75 versus 39.1% at 85-90. This is the study's starting snapshot: it describes how the cohort was recruited and assessed, reports no follow-up results yet, and tests no treatment or prevention.

Study details

Study designlongitudinal study
Participants1,037
Effect size95.5%; 43.5%; 34.8%
Evidence strengthModerate

How this study scored 62/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (International psychogeriatrics)
Journal's citation record	2 / 4	International Psychogeriatrics: journal h-index 161 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	3 / 4	1,037 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 375 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	20.8 citations a year over 18 year(s) since 2010
Impact for its field and year	4 / 6	Cited 14.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 9 other studies in this library
Still being cited	3 / 4	Cited 75 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Ora Lux: h-index 17 (OpenAlex, whole career)
Institution's track record	1 / 3	UNSW Sydney: institution h-index 1,101 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20637138)
Free to read	0 / 2	Behind a paywall — scores zero
Total	62 / 100	—

What each of these 20 components measures, and what this score is not →

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APA 7th

Sachdev, P. S., Brodaty, H., Reppermund, S., Kochan, N. A., Trollor, J. N., Draper, B., et al. (2010). The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years. International psychogeriatrics. https://doi.org/10.1017/s1041610210001067

Vancouver

Sachdev PS, Brodaty H, Reppermund S, Kochan NA, Trollor JN, Draper B, et al. The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years. International psychogeriatrics. 2010. doi:10.1017/s1041610210001067. PMID: 20637138.

BibTeX

@article{sachdev2010-20637138,
  author  = {Sachdev, P. S. and Brodaty, H. and Reppermund, S. and Kochan, N. A. and Trollor, J. N. and Draper, B. and Slavin, M. J. and Crawford, J. and others},
  title   = {{The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years}},
  journal = {International psychogeriatrics},
  year    = {2010},
  doi     = {10.1017/s1041610210001067},
  pmid    = {20637138},
  url     = {https://doi.org/10.1017/s1041610210001067}
}

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