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Accelerated progression from mild cognitive impairment to dementia in people with diabetes
Xu W, Caracciolo B, Wang HX, Winblad B, Bäckman L, Qiu C, Fratiglioni L.. Diabetes, 2010-08-16
Topic: Risk, prevention and care in population studies
Objective The effect of diabetes on mild cognitive impairment (MCI) and its conversion to dementia remains controversial. We sought to examine whether diabetes and pre-diabetes are associated with MCI and accelerate the progression from MCI to dementia. Research design and methods In the Kungsholmen Project, 963 cognitively intact participants and 302 subjects with MCI (120 with amnestic MCI [aMCI] and 182 with other cognitive impairment no dementia [oCIND]) age ≥ 75 years were identified at baseline. The two cohorts were followed for 9 years to detect the incident MCI and dementia following international criteria. Diabetes was ascertained based on a medical examination, hypoglycemic medication use, and random blood glucose level ≥ 11.0 mmol/l. Pre-diabetes was defined as random blood glucose level of 7.8-11.0 mmol/l in diabetes-free participants. Data were analyzed using standard and time-dependent Cox proportional-hazards models. Results During the follow-up period, in the cognitively intact cohort, 182 people developed MCI (42 aMCI and 140 oCIND), and 212 developed dementia. In the MCI cohort, 155 subjects progressed to dementia, the multi-adjusted hazard ratio (95% CI) of dementia was 2.87 (1.30-6.34) for diabetes, and 4.96 (2.27-10.84) for pre-diabetes. In a Kaplan-Meier survival analysis, diabetes and pre-diabetes accelerated the progression from MCI to dementia by 3.18 years. Diabetes and pre-diabetes were neither cross-sectionally nor longitudinally associated with MCI. Conclusions Diabetes and pre-diabetes substantially accelerate the progression from MCI to dementia, and anticipate dementia occurrence by more than 3 years in people with MCI. The association of diabetes with the development of MCI is less evident in old people.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Xu, W., Caracciolo, B., Wang, H. X., Winblad, B., Bäckman, L., Qiu, C., et al. (2010). Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes. https://doi.org/10.2337/db10-0539
Vancouver
Xu W, Caracciolo B, Wang HX, Winblad B, Bäckman L, Qiu C, et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes. 2010. doi:10.2337/db10-0539. PMID: 20713684.
BibTeX
@article{xu2010-20713684,
author = {Xu, W. and Caracciolo, B. and Wang, H. X. and Winblad, B. and Bäckman, L. and Qiu, C. and Fratiglioni, L.},
title = {{Accelerated progression from mild cognitive impairment to dementia in people with diabetes}},
journal = {Diabetes},
year = {2010},
doi = {10.2337/db10-0539},
pmid = {20713684},
url = {https://doi.org/10.2337/db10-0539}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- We sought to examine whether diabetes and pre-diabetes are associated with MCI and accelerate the progression from MCI to dementia.
- Results During the follow-up period, in the cognitively intact cohort, 182 people developed MCI (42 aMCI and 140 oCIND), and 212 developed dementia.
- Diabetes and pre-diabetes were neither cross-sectionally nor longitudinally associated with MCI.
Why it matters
In a 9-year Kungsholmen Project study of people aged 75 and over, those with MCI who had diabetes or pre-diabetes (defined by random blood glucose 7.8-11.0 mmol/l) were more likely to progress to dementia: adjusted hazard ratios were 2.87 for diabetes and 4.96 for pre-diabetes, and progression came about 3.18 years sooner. In people without cognitive problems at the start, diabetes and pre-diabetes were not associated with developing MCI. This is an observational link, not proof of cause, and the study did not test whether treating diabetes changes the outcome.
Study details
- Participants302
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Diabetes) |
| Journal's citation record | 3 / 4 | Diabetes: journal h-index 447 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 302 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 259 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.4 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 3 / 6 | Cited 7.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 17 other studies in this library |
| Still being cited | 3 / 4 | Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Laura Fratiglioni: h-index 133 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Karolinska Institutet: institution h-index 1,477 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20713684) |
| Free to read | 2 / 2 | Free to read |
| Total | 57 / 100 | — |
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