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Chaperone-mediated autophagy markers in Parkinson disease brains
Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, Caballero C, Ferrer I, Obeso JA, Schapira AH.. Archives of neurology, 2010-08-09
Topic: Brain proteins, microglia and lab models
Plain-language summary
Objective To investigate chaperone-mediated autophagy in the pathogenesis of Parkinson disease (PD). Design Postmortem observational study. Setting University Department of Clinical Neuroscience, Institute of Neurology, University College London. Subjects Postmortem samples from 7 PD, 6 Alzheimer disease (AD), and 8 control brains. Main outcome measure Lysosomal-associated membrane protein 2A (LAMP2A) and heat shock cognate 70 (hsc70) protein levels were compared in the substantia nigra pars compacta and amygdala of PD, AD, and control brain samples. To provide insight into the turnover of α-synuclein, degradation pathways for this protein were studied in a dopaminergic cell line. Results The expression levels of the chaperone-mediated autophagy proteins LAMP2A and hsc70 were significantly reduced in the substantia nigra pars compacta and amygdala of PD brains compared with age-matched AD and control brain samples. Lewy bodies in these regions contained autophagy-related proteins. We demonstrated that decreased LAMP2A levels in dopaminergic cell lines reduced chaperone-mediated autophagy activity and increased the half-life of α-synuclein. Conclusions These findings suggest that there is reduced chaperone-mediated autophagy activity in the PD brain, provide evidence for the role of autophagy in PD pathogenesis and Lewy body formation, and suggest that this pathway may be a suitable therapeutic target in PD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Alvarez-Erviti, L., Rodriguez-Oroz, M. C., Cooper, J. M., Caballero, C., Ferrer, I., Obeso, J. A., et al. (2010). Chaperone-mediated autophagy markers in Parkinson disease brains. Archives of neurology. https://doi.org/10.1001/archneurol.2010.198
Vancouver
Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, Caballero C, Ferrer I, Obeso JA, et al. Chaperone-mediated autophagy markers in Parkinson disease brains. Archives of neurology. 2010. doi:10.1001/archneurol.2010.198. PMID: 20697033.
BibTeX
@article{alvarezerviti2010-20697033,
author = {Alvarez-Erviti, L. and Rodriguez-Oroz, M. C. and Cooper, J. M. and Caballero, C. and Ferrer, I. and Obeso, J. A. and Schapira, A. H.},
title = {{Chaperone-mediated autophagy markers in Parkinson disease brains}},
journal = {Archives of neurology},
year = {2010},
doi = {10.1001/archneurol.2010.198},
pmid = {20697033},
url = {https://doi.org/10.1001/archneurol.2010.198}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Results The expression levels of the chaperone-mediated autophagy proteins LAMP2A and hsc70 were significantly reduced in the substantia nigra pars compacta and amygdala of PD brains compared with age-matched AD and control brain samples.
- We demonstrated that decreased LAMP2A levels in dopaminergic cell lines reduced chaperone-mediated autophagy activity and increased the half-life of α-synuclein.
- Conclusions These findings suggest that there is reduced chaperone-mediated autophagy activity in the PD brain, provide evidence for the role of autophagy in PD pathogenesis and Lewy body formation, and suggest that this pathway may be a suitable therapeutic target in PD.
Why it matters
In postmortem brain samples, levels of the chaperone-mediated autophagy proteins LAMP2A and hsc70 were reduced in Parkinson disease brains compared with Alzheimer disease and control brains, and lowering LAMP2A in cells increased the half-life of α-synuclein. This points to autophagy as a possible target in Parkinson disease, not a treatment or cure for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | 3 / 4 | Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 554 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 30.8 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 4 / 6 | Cited 18.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 3 / 4 | Cited 71 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Anthony H.V. Schapira: h-index 129 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad de Navarra: institution h-index 477 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20697033) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
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