Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,876–26,900 of 27,380 studies, newest first · page 1076 of 1096.
April 1992 1
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1992-04-01
The Columbia University Scale for Psychopathology in Alzheimer's disease
47/100 ✓ Peer-reviewed Caregiving Archives of neurology
Key finding: There were significant but weak associations between the presence of specific subtypes of delusions and severity of dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
March 1992 8
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1992-03-01
IRAOS: an instrument for the assessment of onset and early course of schizophrenia
36/100 ✓ Peer-reviewed Clinical safety Schizophrenia research
Key finding: Some results derived from an ongoing study on age and gender differences in onset and patterns of early course are added to demonstrate the use of the instrument.
Full summary, score breakdown and related studies → Original source
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1992-03-01
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
55/100 ✓ Peer-reviewed Getting a diagnosis Journal of Neurology Neurosurgery & Psychiatry
Few detailed clinico-pathological correlations of Parkinson's disease have been published.
Full summary, score breakdown and related studies → Original source
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1992-03-01
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
61/100 ✓ Peer-reviewed Brain tissue and pathology Neurology
Key finding: The degree of neuropathologic change was compared with the severity of dementia, as assessed by the Blessed Dementia Scale and duration of illness. +1 more finding
Full summary, score breakdown and related studies → Original source
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1992-03-01
Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein
46/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: The cellular sites at which this processing occurs are not known. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-03-01
Evidence for a membrane defect in Alzheimer disease brain
50/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue levels of the major membrane phospholipids and their metabolites in three cortical areas from postmortem brains of Alzheimer disease patients and matched controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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1992-03-01
Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers
53/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Key finding: These criteria broaden the conceptualization of vascular dementia, include the results of neuroimaging studies, emphasize the importance of neuropathologic confirmation, refine nosology, and identify areas that require further research.
Full summary, score breakdown and related studies → Original source
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1992-03-01
Alzheimer-type dementia and verbal memory performances: influence of selegiline therapy
49/100 ✓ Peer-reviewed Treatments Italian journal of neurological sciences
Key finding: The results suggest that selegiline possesses significant activity on some memory parameters, which seems to depend on an improvement both in information processing abilities and in learning strategies at the moment of acquisition.
Full summary, score breakdown and related studies → Original source
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1992-03-01
Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage
39/100 ✓ Peer-reviewed Biomarkers Journal of neuroscience research
Key finding: These results suggest that APP production is rapidly upregulated in damaged neurons and accumulates in degenerating axons. +1 more finding
Full summary, score breakdown and related studies → Original source
February 1992 4
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1992-02-01
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
40/100 ✓ Peer-reviewed Disease mechanisms Annals of neurology
Key finding: Recent studies in experimental animals showed that mitochondrial toxins can result in a pattern of neuronal degeneration closely resembling that seen in Huntington's disease, which can be blocked with NMDA antagonists.
Full summary, score breakdown and related studies → Original source
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1992-02-01
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Proceedings of the National Academy of Sciences of the United States of America
Key finding: Over time, we observed selective atrophy of cholinergic neurons in Ts 16 grafts. +2 more findings
Full summary, score breakdown and related studies → Original source
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1992-02-01
Down syndrome: molecular mapping of the congenital heart disease and duodenal stenosis
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of human genetics
Key finding: DS individuals also have characteristic facies, hands, and dermatoglyphics, in addition to abnormalities of the immune system, an increased risk of leukemia, and an Alzheimer-like dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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1992-02-01
Progressive language disorder due to lobar atrophy
44/100 ✓ Peer-reviewed Disparities Annals of neurology
Key finding: Some exhibited nonfluent, agrammatic features, whereas others demonstrated a fluent aphasia, with profound loss of word meaning. +2 more findings
Full summary, score breakdown and related studies → Original source
January 1992 12
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1992-01-01
Working memory
41/100 ✓ Peer-reviewed Digital health tools Science (New York, N.Y.)
Key finding: The term working memory refers to a brain system that provides temporary storage and manipulation of the information necessary for such complex cognitive tasks as language comprehension, learning, and reasoning. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
Cognitive impairment: dementia and Alzheimer's disease
36/100 ✓ Peer-reviewed End-of-life care Annual review of public health
Key finding: Current palliative treatments are attempts to minimize the morbidity of abnormal behaviors and medical complications associated with dementia.
Full summary, score breakdown and related studies → Original source
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1992-01-01
How strictly do dialysis patients want their advance directives followed?
41/100 ✓ Peer-reviewed End-of-life care JAMA
Key finding: Strictly following all advance directives may not truly reflect patients' preferences.
Full summary, score breakdown and related studies → Original source
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1992-01-01
Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease
45/100 ✓ Peer-reviewed Clinical trials Psychopharmacology
Key finding: Nicotine significantly improved sustained visual attention (in both RVIP and DRMLO tasks), reaction time (in both FT and RVIP tasks), and perception (CFF task--both ascending and descending thresholds). +2 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
36/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: One was associated with moderate to marked cerebral amyloid deposition ("pathological aging"), while the other had either minimal or no amyloid deposition ("normal aging"). +2 more findings
Full summary, score breakdown and related studies → Original source
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1992 no date recorded — placed by publication year
Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy
53/100 ✓ Peer-reviewed Lewy body dementia Brain
We report five patients with a stereotyped clinical syndrome characterized by fluent dysphasia with severe anomia, reduced vocabulary and prominent impairment of single-word comprehension, progressing to a stage of virtually complete dissolution of the semantic components of language.
Full summary, score breakdown and related studies → Original source
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1992-01-01
Brain macrophages: evaluation of microglia and their functions
43/100 ✓ Peer-reviewed Inflammation and the immune system Brain research. Brain research reviews
Key finding: Consistent with this cellular identity, they appear to arise from monocytes in developing brain where amoeboid microglia function in removing cell death-associated debris and in regulating gliogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
A neurodevelopmental approach to the classification of schizophrenia
42/100 ✓ Peer-reviewed Brain tissue and pathology Schizophrenia bulletin
Key finding: Instead, much clinical, epidemiological, and morphological evidence suggests that within the broad range of Schneiderian schizophrenia there exists one form (congenital schizophrenia) that can be distinguished from other types, the manifestations of which are confined to adult life. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
A new systematic method of measurement and diagnosis of "mild cognitive impairment" and dementia according to ICD-10 and DSM-III-R criteria
39/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics
Key finding: Using the SIDAM (Structured Interview for the Diagnosis of Dementia of the Alzheimer Type, multi-infarct dementia, and dementias of other etiology according to DSM-III-R and ICD-10), both the dimensional and the categorical aspects of dementia and "mild cognitive impairment" are considered. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease
41/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer disease and associated disorders
Key finding: Much interest centers on the beta A4 amyloid protein, which is progressively deposited in senile plaques and blood vessels in AD brain tissue. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group
49/100 ✓ Peer-reviewed Lewy body dementia Annals of neurology
Key finding: The concept of free radical involvement is supported by enhanced basal lipid peroxidation in substantia nigra in patients with Parkinson's disease, demonstrated by increased levels of malondialdehyde and lipid hydroperoxides. +3 more findings
Full summary, score breakdown and related studies → Original source
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1992-01-01
Down syndrome and Alzheimer disease
33/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Progress in clinical and biological research
Key finding: Certain specific neurons such as those in layer II of entorhinal cortex and the CA1/subiculum field of the hippocampus are exquisitely vulnerable to tangle formation, and are the first neurons to be affected. +4 more findings
Full summary, score breakdown and related studies → Original source
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