Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,351–19,375 of 27,380 studies, newest first · page 775 of 1096.
July 2012 25
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2012-07-10
Brain excitability and connectivity of neuronal assemblies in Alzheimer's disease: from animal models to human findings
43/100 ✓ Peer-reviewed Brain scans and imaging Progress in neurobiology
Key finding: Growing evidence supports the idea that Alzheimer's disease (AD) targets selected and functionally connected neuronal networks and, specifically, their synaptic terminals, affecting brain connectivity well before producing neuronal loss and compartmental atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-06
Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates
43/100 ✓ Peer-reviewed Inflammation and the immune system NeuroImage
Key finding: Microglia play an essential role in many brain diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-06
Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment
44/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: AMCI subjects, when compared to CN subjects, showed significantly reduced right posterior insula volumes, cognitive deficits and disrupted intrinsic connectivity of the insula networks. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-05
Spatial navigation in normal aging and the prodromal stage of Alzheimer's disease: insights from imaging and behavioral studies
36/100 ✓ Peer-reviewed Digital health tools Ageing research reviews
Key finding: Normal aging and mild Alzheimer's disease (AD) are associated with declines in navigational skills, including allocentric and egocentric representations, cognitive mapping, landmark processing, and spatial memory. +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-04
Common hippocampal structural and functional changes in migraine
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain structure & function
Key finding: Migraine is an episodic disorder characterized by intermittent attacks with a number of physiological and emotional stressors associated with or provoking each attack. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-04
Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals
36/100 ✓ Peer-reviewed Prevention trials Nutrition research reviews
Key finding: Most studies considered diet in the frame of a single nutrient approach with inconsistent results. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-03
Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
40/100 ✓ Peer-reviewed Genetics Translational psychiatry
Key finding: We hypothesized that some of these changes are associated with epigenetic modifications of relevant genes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-03
Under-reporting of cardiovascular events in the rofecoxib Alzheimer disease studies
44/100 ✓ Peer-reviewed Treatments American heart journal
Key finding: In the 3 studies combined, the data indicated that rofecoxib more than tripled the risk of confirmed CVT death (risk ratio = 3.57 [1.48-9.72], P = .004). +2 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-02
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
49/100 ✓ Peer-reviewed Risk factors Journal of neuroinflammation
Key finding: Accumulating evidence suggests that neuroinflammation, mediated by the brain's innate immune system, contributes to AD neuropathology and exacerbates the course of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-02
Locus-specific mutation databases for neurodegenerative brain diseases
53/100 ✓ Peer-reviewed Getting a diagnosis Human mutation
Key finding: Such analyses revealed that 61.4% of mutations are private to one single family, while only 5.7% of mutations occur in 10 or more families. +1 more finding
Full summary, score breakdown and related studies → Original source
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2012-07-02
A benefit-finding intervention for family caregivers of persons with Alzheimer disease: study protocol of a randomized controlled trial
62/100 ✓ Peer-reviewed Treatments Trials
Key finding: The emphasis on benefits, rather than losses and difficulties, provides a new dimension to the way interventions for caregivers can be conceptualized and delivered. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-07 month only
Early-onset familial Alzheimer's disease (EOFAD)
38/100 ✓ Peer-reviewed Risk genes beyond APOE The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Key finding: Compared with sporadic Alzheimer's disease (AD), EOFAD has some distinctive features including early age at onset, positive familial history, a variety of non-cognitive neurological symptoms and signs, and a more aggressive course.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
36/100 ✓ Peer-reviewed Disease mechanisms Cold Spring Harbor perspectives in medicine
Key finding: Examples are the large number of structural conformations and biochemical modifications (phosphorylation, proteolysis, glycosylation, and others), the multitude of interaction partners (mainly microtubules, but also other cytoskeletal proteins, kinases, and phosphatases, motor proteins, chaperones, and membrane proteins). +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-01
Overview and findings from the religious orders study
52/100 ✓ Peer-reviewed Brain tissue and pathology Current Alzheimer research
Key finding: The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2012-07-01
N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease
36/100 ✓ Peer-reviewed Treatments Current Alzheimer research
Key finding: While excessive levels of glutamate result in neurotoxicity, in part through the over-activation of NMDARs, memantine-as a partial NMDAR antagonist, blocks the NMDA glutamate receptors to normalize the glutamatergic system and ameliorate cognitive and memory deficits.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
36/100 ✓ Peer-reviewed Drug development British journal of pharmacology
Key finding: Studies have revealed that common pathophysiological features, including oxidative stress, insulin resistance, abnormal protein processing and cognitive decline, occur across these.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Sources of stress for family members of nursing home residents with advanced dementia
52/100 ✓ Peer-reviewed End-of-life care Alzheimer disease and associated disorders
Key finding: Our results support the provision of emotional support to families upon resident admission, education regarding prognosis to guide decision making, improved resident care, and greater communication with health care professionals.
Full summary, score breakdown and related studies → Original source
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2012-07-01
The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study
62/100 ✓ Peer-reviewed Prevention trials The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline.
Full summary, score breakdown and related studies → Original source
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2012-07-01
P3‐402: Detection of PCC functional connectivity characteristics in subcortical vascular mild cognitive impairment: A resting‐state fMRI study
29/100 ✓ Peer-reviewed Risk factors Alzheimer s & Dementia
Key finding: Based on position emission tomography (PET) (5) and structural MRI (sMRI) (3) data sets, neuroimaging studies showed that functional and structural deficits in the cortical brain regions [e.g., the medial frontal cortex, the posterior cingulate cortex (PCC) and the medial temporal lobe] and the subcortical brain regions (e.g., the thalamus and the caudate) in svMCI. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-01
P3‐314: Pictorial education of safe medication for the elderly with cognitive impairment
27/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer s & Dementia
Key finding: All information was provided with both picture and text. +4 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-01
The Framingham Brain Donation Program: neuropathology along the cognitive continuum
49/100 ✓ Peer-reviewed Long-term cohort studies Current Alzheimer research
Key finding: Participants have been undergoing prospective surveillance for incident stroke and dementia and embedded within this cohort is the voluntary Framingham Brain Donation Program that was begun in 1997. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-01
The Modified Mini-Mental State Examination test: normative data for Singapore Chinese older adults and its performance in detecting early cognitive impairment
46/100 ✓ Peer-reviewed Cognitive tests and assessment Singapore medical journal
Key finding: This study aimed to determine the stratified normative data by age and education for a modified version of the Mini-Mental State Examination (MMSE) test from a large sample of community-dwelling Chinese older adults in Singapore, and to examine the MMSE's value in detecting early cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2012-07-01
The Minority Aging Research Study: ongoing efforts to obtain brain donation in African Americans without dementia
52/100 ✓ Peer-reviewed Disparities Current Alzheimer research
Key finding: The results examine strategies for recruiting and consenting African Americans without dementia; (2) efforts to maintain high rates of follow-up participation; (3) strategies for achieving high rates of agreement to brain donation; and (4) the methodology of obtaining rapid brain autopsy at death.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial
72/100 ✓ Peer-reviewed Treatments Annals of neurology
Key finding: Donepezil is safe and well tolerated.
Full summary, score breakdown and related studies → Original source
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2012-07-01
Fruit, vegetables and prevention of cognitive decline or dementia: a systematic review of cohort studies
65/100 ✓ Peer-reviewed Prevention and risk The journal of nutrition, health & aging
Key finding: Nine studies with a total of 44,004 participants met the inclusion criteria. +2 more findings
Full summary, score breakdown and related studies → Original source
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