Home › Research › Prevention and risk
Cognitive impairment and 7-year mortality in dialysis patients
Griva K, Stygall J, Hankins M, Davenport A, Harrison M, Newman SP.. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010-08-25
Topic: Risk, prevention and care in population studies
Background Although dementia has predicted mortality in large dialysis cohorts, little is known about the relationship between less pronounced cognitive deficits and mortality in patients with end-stage renal disease. This study assessed whether cognitive impairment without dementia was an independent predictor of 7-year survival in dialysis patients after controlling for other risk factors. Study design Prospective single-cohort study. Setting & participants 145 prevalent dialysis patients from 2 units in London, UK, were followed up for 64.3 ± 27.4 months and censored at the time of change to a different treatment. Predictors Cognitive impairment, defined as performance 1 standard deviation less than normative values on 2 or more cognitive tests within a neurocognitive battery assessing attention/concentration, memory, and psychomotor function domains. Depression, quality-of-life, and clinical measures also were obtained. Outcomes & measurements All-cause mortality was the primary outcome. Cox proportional hazard models were used to assess the contribution of demographics and clinical and psychological measures and cognitive impairment to mortality. Results 98 (67.6%) patients were cognitively impaired at baseline. At follow-up, 56 (38.6%) patients had died, 29 of cardiac causes. Unadjusted Kaplan-Meier analysis showed higher mortality in cognitively impaired patients, in whom 7-year survival was 49% versus 83.2% in those with no cognitive impairment (P Limitations Small sample size and number of events. Conclusions Cognitive impairment is an independent predictor of mortality in dialysis patients. Although the implications of early recognition and treatment of cognitive impairment for clinical outcomes are unclear, these results suggest that patient management protocols should attempt to ensure prevention of cognitive decline in addition to managing coexisting medical conditions.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Griva, K., Stygall, J., Hankins, M., Davenport, A., Harrison, M., & Newman, S. P. (2010). Cognitive impairment and 7-year mortality in dialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. https://doi.org/10.1053/j.ajkd.2010.07.003
Vancouver
Griva K, Stygall J, Hankins M, Davenport A, Harrison M, Newman SP. Cognitive impairment and 7-year mortality in dialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2010. doi:10.1053/j.ajkd.2010.07.003. PMID: 20800327.
BibTeX
@article{griva2010-20800327,
author = {Griva, K. and Stygall, J. and Hankins, M. and Davenport, A. and Harrison, M. and Newman, S. P.},
title = {{Cognitive impairment and 7-year mortality in dialysis patients}},
journal = {American journal of kidney diseases : the official journal of the National Kidney Foundation},
year = {2010},
doi = {10.1053/j.ajkd.2010.07.003},
pmid = {20800327},
url = {https://doi.org/10.1053/j.ajkd.2010.07.003}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results 98 (67.6%) patients were cognitively impaired at baseline.
- Unadjusted Kaplan-Meier analysis showed higher mortality in cognitively impaired patients, in whom 7-year survival was 49% versus 83.2% in those with no cognitive impairment (P Limitations Small sample size and number of events.
- Although the implications of early recognition and treatment of cognitive impairment for clinical outcomes are unclear, these results suggest that patient management protocols should attempt to ensure prevention of cognitive decline in addition to managing coexisting medical conditions.
Why it matters
In this small cohort of 145 dialysis patients, cognitive impairment was linked to higher mortality, but the study did not test any treatment, cure, or prevention for Alzheimer's disease. The authors note that the implications of early recognition and treatment of cognitive impairment for clinical outcomes are unclear.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designcohort study
- Effect sizeor 64.3; 67.6%; 38.6%
- Evidence strengthModerate
How this study scored 57/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of kidney diseases : the official journal of the National Kidney Foundation) |
| Journal's citation record | 3 / 4 | American Journal of Kidney Diseases: journal h-index 293 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 258 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.3 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 4 / 6 | Cited 8.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 47 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Stanton Peter Newman: h-index 81 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20800327) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
1 study in the alzhub library lists this one in its references.
Related studies in Prevention and risk
Also tagged “palliative”
858 studies in the library carry the topic tag “palliative”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 858 tagged studies.