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All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study
Nüesch E, Dieppe P, Reichenbach S, Williams S, Iff S, Jüni P.. BMJ (Clinical research ed.), 2011-03-08
Topic: Risk, prevention and care in population studies
Objective To examine all cause and disease specific mortality in patients with osteoarthritis of the knee or hip. Design Population based cohort study. Setting General practices in the southwest of England. Participants 1163 patients aged 35 years or over with symptoms and radiological confirmation of osteoarthritis of the knee or hip. Main outcome measures Age and sex standardised mortality ratios and multivariable hazard ratios of death after a median of 14 years' follow-up. Results Patients with osteoarthritis had excess all cause mortality compared with the general population (standardised mortality ratio 1.55, 95% confidence interval 1.41 to 1.70). Excess mortality was observed for all disease specific causes of death but was particularly pronounced for cardiovascular (standardised mortality ratio 1.71, 1.49 to 1.98) and dementia associated mortality (1.99, 1.22 to 3.25). Mortality increased with increasing age (P for trend Conclusion Patients with osteoarthritis are at higher risk of death compared with the general population. History of diabetes, cancer, or cardiovascular disease and the presence of walking disability are major risk factors. Management of patients with osteoarthritis and walking disability should focus on effective treatment of cardiovascular risk factors and comorbidities, as well as on increasing physical activity.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nüesch, E., Dieppe, P., Reichenbach, S., Williams, S., Iff, S., & Jüni, P. (2011). All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ (Clinical research ed.). https://doi.org/10.1136/bmj.d1165
Vancouver
Nüesch E, Dieppe P, Reichenbach S, Williams S, Iff S, Jüni P. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ (Clinical research ed.). 2011. doi:10.1136/bmj.d1165. PMID: 21385807.
BibTeX
@article{nuesch2011-21385807,
author = {Nüesch, E. and Dieppe, P. and Reichenbach, S. and Williams, S. and Iff, S. and Jüni, P.},
title = {{All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study}},
journal = {BMJ (Clinical research ed.)},
year = {2011},
doi = {10.1136/bmj.d1165},
pmid = {21385807},
url = {https://doi.org/10.1136/bmj.d1165}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results Patients with osteoarthritis had excess all cause mortality compared with the general population (standardised mortality ratio 1.55, 95% confidence interval 1.41 to 1.70).
- Mortality increased with increasing age (P for trend Conclusion Patients with osteoarthritis are at higher risk of death compared with the general population.
Why it matters
In this cohort, people with knee or hip osteoarthritis had higher death rates than the general population, including higher dementia-associated mortality. This is an observational link between osteoarthritis and mortality, not a treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Study designcohort study
- Participants1,163
- Evidence strengthModerate
How this study scored 69/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (BMJ (Clinical research ed.)) |
| Journal's citation record | 4 / 4 | BMJ: journal h-index 608 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,163 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 727 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 42.8 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 5 / 6 | Cited 26.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 105 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Peter Jüni: h-index 165 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Bristol: institution h-index 1,260 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21385807) |
| Free to read | 2 / 2 | Free to read |
| Total | 69 / 100 | — |
What each of these 20 components measures, and what this score is not →
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