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Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study
Melissa Erin Murray, Neill R. Graff‐Radford, Owen A. Ross, Ronald Carl Petersen, Ranjan Duara, Dennis W. Dickson. The Lancet Neurology, 2011-07-29
Topic: Amyloid, tau and blood-test diagnosis
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Key findings
- Hippocampal sparing cases had less hippocampal atrophy than did typical and limbic-predominant cases.
- Clinical presentation, age at onset, disease duration, and rate of cognitive decline differed between the AD subtypes.
- Patients with hippocampal sparing AD were younger at death and a higher proportion of them were men, whereas those with limbic-predominant AD were older and a higher proportion of them were women.
Why it matters
Describes subtypes of Alzheimer's disease defined by neuropathology that had distinct clinical characteristics, in a retrospective study.
How this study scored 57/100
Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 54 of the 95 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (The Lancet Neurology) |
| Journal's citation record | 3 / 4 | The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 975 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 57.4 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 5 / 6 | Cited 26.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 217 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Dennis W. Dickson: h-index 218 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21802369) |
| Free to read | 2 / 2 | Free to read |
| Points | 54 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 95 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s1474-4422(11)70156-9
- PubMed: 21802369
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Murray, M. E., Graff‐Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011). Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(11)70156-9
Vancouver
Murray ME, Graff‐Radford NR, Ross OA, Petersen RC, Duara R, Dickson DW. Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study. The Lancet Neurology. 2011. doi:10.1016/s1474-4422(11)70156-9. PMID: 21802369.
BibTeX
@article{murray2011-21802369,
author = {Murray, Melissa Erin and Graff‐Radford, Neill R. and Ross, Owen A. and Petersen, Ronald Carl and Duara, Ranjan and Dickson, Dennis W.},
title = {{Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study}},
journal = {The Lancet Neurology},
year = {2011},
doi = {10.1016/s1474-4422(11)70156-9},
pmid = {21802369},
url = {https://doi.org/10.1016/s1474-4422(11)70156-9}
}
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