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Human Alzheimer and inflammation biomarkers after anesthesia and surgery
Tang JX, Baranov D, Hammond M, Shaw LM, Eckenhoff MF, Eckenhoff RG.. Anesthesiology, 2011-10-01
Topic: Amyloid, tau and blood-test diagnosis
Background The prevalence of postoperative cognitive disturbance, coupled with growing in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls for additional study of the interaction between surgical care and Alzheimer neuropathology. The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery. Methods Eleven patients undergoing idiopathic nasal CSF leak correction were admitted to this Institutional Review Board-approved study.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tang, J. X., Baranov, D., Hammond, M., Shaw, L. M., Eckenhoff, M. F., & Eckenhoff, R. G. (2011). Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology. https://doi.org/10.1097/aln.0b013e31822e9306
Vancouver
Tang JX, Baranov D, Hammond M, Shaw LM, Eckenhoff MF, Eckenhoff RG. Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology. 2011. doi:10.1097/aln.0b013e31822e9306. PMID: 21857497.
BibTeX
@article{tang2011-21857497,
author = {Tang, J. X. and Baranov, D. and Hammond, M. and Shaw, L. M. and Eckenhoff, M. F. and Eckenhoff, R. G.},
title = {{Human Alzheimer and inflammation biomarkers after anesthesia and surgery}},
journal = {Anesthesiology},
year = {2011},
doi = {10.1097/aln.0b013e31822e9306},
pmid = {21857497},
url = {https://doi.org/10.1097/aln.0b013e31822e9306}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery.
- Methods Eleven patients undergoing idiopathic nasal CSF leak correction were admitted to this Institutional Review Board-approved study.
- Lumbar subarachnoid catheters were placed before the procedure.
- Anesthesia was total intravenous propofol or remifentanil or inhalational sevoflurane, depending on provider choice.
Why it matters
This study measured cerebrospinal fluid biomarkers in only 11 patients undergoing surgery for nasal CSF leak, to look at whether anesthesia and surgery affect Alzheimer-related markers. The sample is very small and preliminary, and no treatment, cure, or prevention is shown.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Anesthesiology) |
| Journal's citation record | 3 / 4 | Anesthesiology: journal h-index 368 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 208 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 12.2 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 3 / 6 | Cited 4.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Roderic G. Eckenhoff: h-index 56 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Pennsylvania: institution h-index 1,859 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21857497) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1097/aln.0b013e31822e9306
- PubMed: 21857497
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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